Protein Alignment 5-HT1A and hrh2a

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001038803.2
• Gene: hrh2a / 735303
• ZFINID: ZDB-GENE-070531-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 612
• Identity: 120/612 - (19%)
• Similarity: 175/612 - (28%)
• Gaps: 316/612 - (51%)

  Fly   221 TQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAV 285
            |..:.:|||   |.::||:|:.||:.|..|:...|.|:||.|..:.||||.|..:..||:|...:
Zfish     2 TSQIALAVT---LSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTL 63

  Fly   286 YEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCV 349
            |:::..|.||...|:|:.|.||:.||||||:|.||::|||:||| .:.|.......||..::..:
Zfish    64 YQVTGDWPLGAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAILATI 128

  Fly   350 WTAAVIVSLAP-QFGWKDPDY-LQRIEQ----QKCMVSQDVSYQVFATCCTFYVPLLVILALYWK 408
            |..:|.||..| ..||...|. :|.|.:    :.|....:.:|.:.....|||:|||.:...|.:
Zfish   129 WLVSVGVSFVPIHLGWNTRDLSVQNIREGDHARDCRFELNPTYAIVDAFSTFYLPLLAMCWSYHR 193

  Fly   409 IYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASG 473
            :::.||.|..|                                 ..||.:..|
Zfish   194 VFRIARMRAKR---------------------------------IISTRRGST------------ 213

  Fly   474 GRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAK 538
                                                                             
Zfish   214 ----------------------------------------------------------------- 213

  Fly   539 SSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKAN 603
                                                                             
Zfish   214 ----------------------------------------------------------------- 213

  Fly   604 GVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGP 668
                                                               :||||
Zfish   214 ---------------------------------------------------SSQGV--------- 218

  Fly   669 MTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQK 733
                                                                             
Zfish   219 ----------------------------------------------------------------- 218

  Fly   734 VNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNS 798
                  |:...||.||..|||::.|||||||.|:|.....|.:........:..|:.|||||.||
Zfish   219 ------TILTLREHKATVTLAVVLGAFVVCWFPYFTFFTIMGIRNEENPPQTAQSVVLWLGYANS 277

  Fly   799 TLNPVIYTIFSPEFRQAFKRILFGGHR 825
            .||||:|...:.:||.|:.::|.||.|
Zfish   278 ALNPVLYATLNRDFRSAYAKLLCGGRR 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	70/192 (36%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	9/25 (36%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	7/22 (32%)
		TM helix 5	383..412	CDD:320454	8/28 (29%)
		7tm_GPCRs	<743..816	CDD:475119	32/72 (44%)
		TM helix 6	750..772	CDD:410628	12/21 (57%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
hrh2a	NP_001038803.2	7tmA_Histamine_H2R	5..295	CDD:320179	114/598 (19%)
		TM helix 1	6..32	CDD:320179	11/28 (39%)
		TM helix 2	39..66	CDD:320179	10/26 (38%)
		TM helix 3	77..107	CDD:320179	18/29 (62%)
		TM helix 4	119..139	CDD:320179	6/19 (32%)
		TM helix 5	168..198	CDD:320179	8/29 (28%)
		TM helix 6	223..253	CDD:320179	16/29 (55%)
		TM helix 7	263..288	CDD:320179	13/24 (54%)