Protein Alignment 5-HT1A and LOC567498

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001430360.1
• Gene: LOC567498 / 567498
• -ID: -
• Length: 398
• Species: Danio rerio
• Alignment Length: 600
• Identity: 119/600 - (19%)
• Similarity: 182/600 - (30%)
• Gaps: 314/600 - (52%)

  Fly   233 LGLMILVTIIGNVFVIAAIILERNLQ-NVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGP 296
            |.|::|.|::||..|.||::..|:|: .|.|..:.|||::||.||.||||..|..|::..|..|
Zfish    28 LSLLVLWTLLGNFMVCAAVLRFRHLRGKVTNVFIVSLAMSDLLVAVLVMPWKAATEVTGHWAFG- 91

  Fly   297 ELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNR--VFMMIFCVWTAAVIVSLA 359
            ..|:.|.:.|::|.|||||:|..|::|||||::: .:.:.|..||  ..:|:...|..:|.:|..
Zfish    92 SFCECWVAFDIMCSTASILNLCVISLDRYWAISD-PFQYERKMNRRVALVMVSVTWIVSVAISFV 155

  Fly   360 P-QFGWKDPDYLQRIE------QQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRI 417
            | |..|...| |..:.      ::.|..|...:|.:.::..:||:|:.|:|..|.:||:.|
Zfish   156 PVQLNWHRAD-LDTVNTSNWTTKEMCDSSLSRTYAISSSLISFYIPVAVMLVTYTRIYRIA---- 215

  Fly   418 HRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDG 482
                                                                             
Zfish   216 ----------------------------------------------------------------- 215

  Fly   483 NSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMA 547
                                                                             
Zfish   216 ----------------------------------------------------------------- 215

  Fly   548 PSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQ 612
                                                                             
Zfish   216 ----------------------------------------------------------------- 215

  Fly   613 LQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLT 677
                  |:|                     |.|||:|......:|
Zfish   216 ------QIQ---------------------IKSISSLERAAERAQ-------------------- 233

  Fly   678 SCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLE 742
            ||:.....|                                           |:|.        .
Zfish   234 SCSAGARTC-------------------------------------------PLQH--------R 247

  Fly   743 AKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLC--AACQISDSVASLFLWLGYFNSTLNPVIY 805
            |.||.|..|||::|.|.||.||.||||:...:|.|  ..| :|::..::|:|.|:.||:|||:||
Zfish   248 AIRETKLFKTLSVIMGVFVCCWFPFFVLNCAVPFCHKPDC-VSEATFNVFVWFGWCNSSLNPIIY 311

  Fly   806 TIFSPEFRQAFKRIL 820
            . |:.:||.||.|:|
Zfish   312 A-FNSDFRDAFARLL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/189 (35%)
		TM helix 1	228..254	CDD:320454	9/20 (45%)
		TM helix 2	261..287	CDD:320454	13/25 (52%)
		TM helix 3	299..329	CDD:320454	16/29 (55%)
		TM helix 4	340..362	CDD:320454	7/24 (29%)
		TM helix 5	383..412	CDD:320454	9/28 (32%)
		7tm_GPCRs	<743..816	CDD:475119	34/74 (46%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	10/24 (42%)
LOC567498	NP_001430360.1	None