Protein Alignment 5-HT1A and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 965
• Identity: 218/965 - (22%)
• Similarity: 343/965 - (35%)
• Gaps: 288/965 - (29%)

  Fly    66 NNNNSKRYYSSGKRRADFIGSLALKPPPTDVNTTTTTAGSPLATAALAAAAASASVAAAAARITA 130
            |::..:.:..|.::...|:...::..|...::.|        ||..||.|.....|...|..:..
Mosquito     7 NDDPVEMWLWSSRKPVQFVRLSSVPFPSPHLSGT--------ATVTLAGATVGVGVRGLAGGLVR 63

  Fly   131 KAAHRALTT--KQ-DATSSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEML 192
            ..|:....:  || :.|.:|        ||   |.|....|||.    |.  ::.:|.
Mosquito    64 PPAYTGYVSYMKQFNFTGNP--------ID---NRTGAEAGLGP----DR--IDADDD------- 104

  Fly   193 ANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNL 257
                                    |||.:.|......::|..:::..|..||:.|..||:.||.|
Mosquito   105 ------------------------EDDGSSLALHNYWALLAIILVFGTAAGNILVCLAIVWERRL 145

  Fly   258 QNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAV 322
            |||.||.:.|||:.||.||..|||||.:..:...:.|..|.|.:|...|||.|||||:||..|:|
Mosquito   146 QNVTNYFLMSLAITDLMVALSVMPLGILTLVKGHFPLDSEYCLVWICLDVLFCTASIMHLCTISV 210

  Fly   323 DRYWAVT-NIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSY 386
            |||.::. .:.:..::|..||.:.|..||..::.:|| |.......::...:....|.:...| |
Mosquito   211 DRYLSLRYPMKFGRNKTRRRVVLKISFVWLLSIAMSL-PLSLMYSKNHASVLVDGTCQIPDPV-Y 273

  Fly   387 QVFATCCTFYVPLLVILALY--------------------------WKIYQTA--RKRIHRRRPR 423
            ::..:...||:||.|:|..|                          |.....|  |:...:|..:
Mosquito   274 KLVGSIVCFYIPLCVMLITYTLTVRLLAQQSENLGGVGSGGGWSSGWLGQAPAFDRRNTWKRIIK 338

  Fly   424 PVDAAVNNNQPDGGAATDTKL-----HRLRL-----------------RLGRFSTAKSKTGSAVG 466
            ....|..|......|:|||:|     |.|.|                 |.|......|:...:|.
Mosquito   339 LSLPAAQNPHAHSAASTDTELSTLDNHDLWLLESSIPEPSSITMTAMQRFGEEMLKLSQGLESVA 403

  Fly   467 VSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSK------SRAGVEAPSTSGNQIATVSHL 525
            .....:.|:     :|:|.:...:.|...|.....::|      :...|.:|..|..:.::.|..
Mosquito   404 QHSDRNSGQ-----NGSSRSPEPSREKESFRKKPANAKHAPTPVTMVTVRSPVPSKKRRSSTSTW 463

  Fly   526 VA-----------LAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQ--- 576
            :|           |.:::.||..      :.:.|..  .||.:..|...|:...||.|::::
Mosquito   464 IARRNSGTPPPVRLVRKRFKSLP------HALPPPA--SDDIEVDEQFMQDVLYELRDREDRGSV 520

  Fly   577 ------------------------------------VGPQ---PTTATSAMTAAGTNESEDQCK- 601
                                                .||:   |..|.| .||| |.:....||
Mosquito   521 HGSSARPGAAGLDGVPAAASRATSDRREGRDAGSNPAGPRQAHPLAAPS-QTAA-TLKLPPPCKC 583

  Fly   602 ---ANGVEVLEDPQLQQQLE--QVQQLQKSVKSGGGGGA---------------STSNATT---- 642
               ..|.     |..||.|.  :::.::.|...|..|||               |.||.||
Mosquito   584 PFFGEGA-----PGRQQYLRPAEIKIVKTSTDFGPMGGAASNGDSLVYSTISISSGSNVTTQPTR 643

  Fly   643 --ITSISAL------SPQTPTSQGVGIAAAA---------------------AGPMTAKTSTLT- 677
              .:|:|.|      ||....|...||:...                     ..|..|..|:::
Mosquito   644 SISSSLSTLPASALASPSRKGSAPKGISVVTWDQRRHQRRGSSFGGARTSLLLTPTKASPSSVSL 708

  Fly   678 --SCNQSHPLC--------GTANES--PSTPEPRSRQPTTPQQQ------------------PHQ 712
              |.|..|...        |:|.|:  ...|:..|..|...|.|                  ...
Mosquito   709 RRSINLRHSALEGGGGGGGGSAGETMFRGAPKKNSSSPCLMQHQTGGGGGGGAVGGGNGTAVAMM 773

  Fly   713 QAHQQQQQQQQLSSIANPMQKVNKRKETLEAKR----------ERKAAKTLAIITGAFVVCWLPF 767
            ...........|::....::..:.|..::.::.          |:||.|.|.::...||:.|.||
Mosquito   774 AVAAASSTVPTLATTTMAVRSHHSRNSSMISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWAPF 838

  Fly   768 FVMALTMPLCAACQ--ISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ||:.|...:|..|:  |...|.....||||.:|.:||:.||||:..||.||:::|
Mosquito   839 FVLNLLPSVCKHCEDNIDQWVFEFVTWLGYASSLVNPIFYTIFNKAFRDAFRKVL 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	66/212 (31%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	8/21 (38%)
		TM helix 5	383..412	CDD:320454	10/54 (19%)
		7tm_GPCRs	<743..816	CDD:475119	30/84 (36%)
		TM helix 6	750..772	CDD:410628	9/21 (43%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
5-HT2B	XP_061501050.1	None