Protein Alignment 5-HT1A and adrb2a

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001096122.1
• Gene: adrb2a / 565838
• ZFINID: ZDB-GENE-100414-3
• Length: 405
• Species: Danio rerio
• Alignment Length: 626
• Identity: 135/626 - (21%)
• Similarity: 189/626 - (30%)
• Gaps: 321/626 - (51%)

  Fly   209 NVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADL 273
            |...|..:|      |:|.|...|:.:::|:.:.|||.||.||...:.||||.|..:.|||.|||
Zfish    17 NTNASTKSE------LQMTVLGTLMSILVLIIVFGNVMVITAISRFQRLQNVTNCFITSLACADL 75

  Fly   274 FVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSR 337
            .:..:|:|.||:|.|...|..|..|||.||:.||||.||||..|..||:|||.|:|: ..|....
Zfish    76 VMGLVVIPFGALYIILNTWHFGHFLCDFWTATDVLCVTASIETLCVIAMDRYIAITSPFRYQSLL 140

  Fly   338 TSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRIEQQKCMVSQ------DV--SYQVFATCC 393
            |.||...::..||..|.:||..| ...|    ::....:..|..:.      |:  ||.:.::..
Zfish   141 TKNRARFIVLMVWVIAGLVSYLPIHMEW----WISTDNETLCCYNNTYCCEFDITYSYAIVSSII 201

  Fly   394 TFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAK 458
            :||:||::::.:|.:::|.|||::.:         :|..:                  |||...|
Zfish   202 SFYIPLVIMVFVYSRVFQEARKQLKK---------INKTE------------------GRFHAQK 239

  Fly   459 SKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVS 523
            |                       ||.|
Zfish   240 S-----------------------NSRN------------------------------------- 244

  Fly   524 HLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAM 588
                                                             ||
Zfish   245 -------------------------------------------------QD-------------- 246

  Fly   589 TAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQT 653
              ...|.||
Zfish   247 --VANNHSE-------------------------------------------------------- 253

  Fly   654 PTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQ 718
                                                                             
Zfish   254 ----------------------------------------------------------------- 253

  Fly   719 QQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQIS 783
                        |:...|.|..|   :|.||.|||.||.|.|.:|||||||:.: :|       .
Zfish   254 ------------MRSTKKAKFYL---KEHKALKTLGIIMGVFTLCWLPFFVLNV-IP-------K 295

  Fly   784 DSV----ASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            .||    ..:..|:||.||..||:|| ..||:||.|||.||
Zfish   296 GSVDIWTFRILNWIGYANSAFNPLIY-CGSPDFRYAFKEIL 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	71/195 (36%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	19/29 (66%)
		TM helix 4	340..362	CDD:320454	8/22 (36%)
		TM helix 5	383..412	CDD:320454	8/30 (27%)
		7tm_GPCRs	<743..816	CDD:475119	33/76 (43%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	11/28 (39%)
adrb2a	NP_001096122.1	7tm_GPCRs	31..331	CDD:475119	124/600 (21%)
		TM helix 1	31..55	CDD:410628	9/23 (39%)
		TM helix 2	64..86	CDD:410628	9/21 (43%)
		TM helix 3	102..124	CDD:410628	13/21 (62%)
		TM helix 4	147..163	CDD:410628	5/15 (33%)
		TM helix 5	192..215	CDD:410628	6/22 (27%)
		TM helix 6	270..291	CDD:410628	14/20 (70%)
		TM helix 7	300..325	CDD:410628	9/25 (36%)