Protein Alignment 5-HT1A and htr1b

DIOPT Version :9

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001122181.1
• Gene: htr1b / 561647
• ZFINID: ZDB-GENE-081022-141
• Length: 380
• Species: Danio rerio
• Alignment Length: 636
• Identity: 164/636 - (25%)
• Similarity: 238/636 - (37%)
• Gaps: 275/636 - (43%)

  Fly   195 RSG-------QLDLINGTGGLNVT-TSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAI 251
            |||       ..:::|.:.|.||| |.|..|...:...::.::|| |||:.|.||:.|.||||.|
Zfish     3 RSGYFKPTPAHFEVLNSSTGTNVTLTPKTDEKQESFAFQVTLSSV-LGLITLATILSNAFVIATI 66

  Fly   252 ILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILH 316
            ...|.||..||:|:|||||.||.|:.||||:..:|.:::.|.||..:||||.|.|:.||||||||
Zfish    67 SQSRKLQTPANFLIASLAVTDLLVSVLVMPICVLYTVTREWTLGQVICDIWLSSDITCCTASILH 131

  Fly   317 LVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMV 380
            |..||:|||||:|: ::|...||..|...|:...|..|:.:|| |.|.|:.   ::..|...|.|
Zfish   132 LCVIALDRYWAITDAVEYAKKRTQARAAGMVATAWIIAISISL-PPFFWRQ---VKAGELTTCSV 192

  Fly   381 SQD-VSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKL 444
            :.| :.|.:::|...||:|.|:::|||.:||..|||||.::.|:
Zfish   193 NTDHIFYTIYSTFGAFYIPTLLLIALYGRIYVEARKRILKQSPK--------------------- 236

  Fly   445 HRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGV 509
                      ...|..|.:.:..:.|||
Zfish   237 ----------KPGKRLTSAHLSTNSPAS------------------------------------- 254

  Fly   510 EAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQD 574
                     :|:.|.|                      ..|||
Zfish   255 ---------VASTSPL----------------------HCGRQ---------------------- 266

  Fly   575 EQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSN 639
                                   |.|..:| .:..|.|::
Zfish   267 -----------------------DLCSDSG-SLGSDNQIR------------------------- 282

  Fly   640 ATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPT 704
                                         :|...|.|
Zfish   283 -----------------------------VTVSDSLL---------------------------- 290

  Fly   705 TPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFV 769
                                            .|:.:.|.|||||.|||.||.||::|||||||:
Zfish   291 --------------------------------EKKRISAARERKATKTLGIILGAYIVCWLPFFI 323

  Fly   770 MALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ..|.:|||::| .|..:...|.||||.||.:||:|||:.:.:|::||.:::
Zfish   324 YTLLIPLCSSC-FSPELFDFFTWLGYVNSLINPIIYTMSNDDFKKAFHKVI 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	86/187 (46%)
		TM helix 1	228..254	CDD:320454	14/25 (56%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	22/29 (76%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	12/29 (41%)
		7tm_GPCRs	<743..816	CDD:355774	39/72 (54%)
		TM helix 6	747..772	CDD:341315	17/24 (71%)
		TM helix 7	784..809	CDD:341315	12/24 (50%)
htr1b	NP_001122181.1	7tm_1	59..358	CDD:278431	139/562 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920