Protein Alignment 5-HT1A and adrb1

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001122161.1
• Gene: adrb1 / 557194
• ZFINID: ZDB-GENE-081022-145
• Length: 390
• Species: Danio rerio
• Alignment Length: 600
• Identity: 119/600 - (19%)
• Similarity: 181/600 - (30%)
• Gaps: 314/600 - (52%)

  Fly   231 VLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILG 295
            :|:||::.|.::||:.||.||...:.||.:.|..:.|||.|||.:..||:|.||..|:...|:.|
Zfish    33 ILMGLIVFVIVVGNILVIVAIARNQRLQTLTNVFIVSLACADLIMGLLVVPFGAALEVRGAWMYG 97

  Fly   296 PELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLA 359
            ...|:.|.|.||||.||||..|..||:|||.|:.: ..|....|..|..:::..||..:.:||..
Zfish    98 SFFCEFWISLDVLCVTASIETLCVIAIDRYIAIISPFRYQSLLTKARAKVVVCAVWAISALVSFP 162

  Fly   360 P-QFGWKDPDYLQRIEQQKCMVSQDV-------SYQVFATCCTFYVPLLVILALYWKIYQTARKR 416
            | ...|.     |..|:..|..:.:.       :|.:.::..:||:||:|::.:|.::|:.|:::
Zfish   163 PILMHWS-----QDSEETSCYENPECCDFVTNRAYAISSSIISFYIPLIVMIFVYARVYREAKQQ 222

  Fly   417 IHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVD 481
            :
Zfish   223 L---------------------------------------------------------------- 223

  Fly   482 GNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGM 546
                |.:|..|...:::
Zfish   224 ----NKINKCEGRFYNN------------------------------------------------ 236

  Fly   547 APSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDP 611
                          ||
Zfish   237 --------------HG------------------------------------------------- 238

  Fly   612 QLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTL 676
                                                                             
Zfish   239 ----------------------------------------------------------------- 238

  Fly   677 TSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETL 741
            |:|                      :||                              .||...:
Zfish   239 TNC----------------------KPT------------------------------RKRTTKI 251

  Fly   742 EAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFL-WLGYFNSTLNPVIY 805
            .|.:|:||.|||.||.|.|.:||||||::.:....||  |:.|....:|| ||||.||..||:||
Zfish   252 LALKEQKALKTLGIIMGTFTLCWLPFFIVNVVRVFCA--QVVDKELFVFLNWLGYVNSAFNPIIY 314

  Fly   806 TIFSPEFRQAFKRIL 820
             ..||:||:||||:|
Zfish   315 -CRSPDFRKAFKRLL 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	65/190 (34%)
		TM helix 1	228..254	CDD:320454	10/22 (45%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	6/22 (27%)
		TM helix 5	383..412	CDD:320454	8/35 (23%)
		7tm_GPCRs	<743..816	CDD:475119	37/73 (51%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	13/25 (52%)
adrb1	NP_001122161.1	7tm_GPCRs	30..324	CDD:475119	114/594 (19%)
		TM helix 1	31..55	CDD:320624	10/21 (48%)
		TM helix 2	64..86	CDD:320624	10/21 (48%)
		TM helix 3	102..124	CDD:320624	12/21 (57%)
		TM helix 4	147..163	CDD:320624	4/15 (27%)
		TM helix 5	190..213	CDD:320624	6/22 (27%)
		TM helix 6	260..282	CDD:320624	13/21 (62%)
		TM helix 7	293..318	CDD:320624	12/25 (48%)