DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT1A and or90h4

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001129719.1	Gene:	or90h4 / 556415	ZFINID:	ZDB-GENE-070806-23	Length:	315	Species:	Danio rerio

Alignment Length:	275	Identity:	52/275 - (18%)
Similarity:	109/275 - (39%)	Gaps:	73/275 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVI---AAIILERNLQNVANYLVASLA 269
            :|.|...|  |::.:.:...:..|.|.|  :|.:|..:.|:   ::.:..|:.:.:   |...|.
Zfish    11 MNTTVWIV--DNYQEAITKHIVIVFLAL--IVNVINGMLVVTFFSSHVFSRDSRYI---LYIHLV 68

  Fly   270 VADLFVACLVMPLGAVYEISQ-GWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDY 333
            :.|:.:.|..:   |:|.::. ..::...||.|..|...:....:.|:|..:|::|:.||.. ..
Zfish    69 INDMLMICASV---AIYVLTYIAPVVNASLCYILMSLGKVFFMITPLNLAGMAIERFIAVCK-PL 129

  Fly   334 IHSR--TSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVS-YQVFATCC-T 394
            .||:  |..|.::....:|..|.|.|:              ::....:::|.:| ::.|..|. |
Zfish   130 HHSQICTPQRTYVFFCLLWGIAAIRSV--------------VDIMISLLTQPISFFRSFVPCYPT 180

  Fly   395 FYVP-------------------LLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAAT 440
            :..|                   .::|...|.::...|||.:.:                 |:|:
Zfish   181 YMFPSKAHDDHNTASQVICMSMVWIIICYTYCRVLFAARKAVSK-----------------GSAS 228

  Fly   441 DTK----LHRLRLRL 451
            ..:    ||.::|.|
Zfish   229 KARSTILLHGVQLLL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	39/212 (18%)
		TM helix 1	228..254	CDD:320454	6/28 (21%)
		TM helix 2	261..287	CDD:320454	5/25 (20%)
		TM helix 3	299..329	CDD:320454	8/29 (28%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	7/49 (14%)
		7tm_GPCRs	<743..816	CDD:355774
		TM helix 6	747..772	CDD:341315
		TM helix 7	784..809	CDD:341315
or90h4	NP_001129719.1	7tm_4	32..>161	CDD:304433	31/151 (21%)
or90h4	NP_001129719.1	7tm_1	42..288	CDD:278431	43/240 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100