DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and drd4-rs

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_001012638.3 Gene:drd4-rs / 503566 ZFINID:ZDB-GENE-051113-172 Length:418 Species:Danio rerio


Alignment Length:632 Identity:156/632 - (24%)
Similarity:241/632 - (38%) Gaps:238/632 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 LNVTTS---KVAEDDFTQLLRMAVTSVLLGL-MILVTIIGNVFVIAAIILERNLQNVANYLVASL 268
            :|||.|   ..|.:.:..|      :::.|: :||:.|:|||.|..:::.||:|:...||.:.||
Zfish     2 VNVTPSIDPTAAHEGYNYL------ALICGVPLILIIILGNVLVCLSVLTERSLKTATNYFIVSL 60

  Fly   269 AVADLFVACLVMPLGAVYEISQG-WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWA-VTNI 331
            |||||.:|.||:||....|...| |.|...:||...:.||:.||||||:|.||:||||.| |..:
Zfish    61 AVADLLLAILVLPLYVYSEFLGGIWTLSMYICDALMTMDVMLCTASILNLCAISVDRYIAVVVPL 125

  Fly   332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQK---CMVSQDVSYQVFATCC 393
            .|..::.|.|...:|...|..::.|:....||      |.::..:.   |.: :|..:.|:::.|
Zfish   126 KYNRNQFSVRQLALITATWVLSLGVASPVIFG------LNQVPNRNPHVCKL-EDNQFVVYSSVC 183

  Fly   394 TFYVPLLVILALYW------KIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLG 452
            :|:||..|:|.||:      |.:.:.|.|.|.|||           |.|..:       |.||||
Zfish   184 SFFVPCPVMLFLYYWMFRGLKRWSSGRNRSHLRRP-----------PRGRRS-------LSLRLG 230

  Fly   453 RFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGN 517
                                                                             
Zfish   231 ----------------------------------------------------------------- 230

  Fly   518 QIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPT 582
                    .||.|::|::..|    |..:.|:|.                            .||
Zfish   231 --------AALQKEKGRAREK----VVYLMPAGL----------------------------SPT 255

  Fly   583 TATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSIS 647
            :.|                                                      ||..|.||
Zfish   256 SLT------------------------------------------------------ATPTTPIS 266

  Fly   648 ALSPQTPTSQGVG---IAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQ-PTTPQQ 708
            :.||.|.|:..:.   :..|.:.|||.:..:::...         |...:|.:...|: ......
Zfish   267 STSPVTLTTDDLAEGQMPGAESDPMTTQMDSVSDAE---------NPERATEDDSGRENGVGKNH 322

  Fly   709 QPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALT 773
            :||  ..::..:..::|.                  |||||.|.|.::.|.|:.||.||||:.:|
Zfish   323 RPH--TGRRHSKSNRVSG------------------RERKAMKVLPVVVGVFLACWTPFFVVHVT 367

  Fly   774 MPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ..||.:|.|..::.|:..||||.||.:||:|||.|:.|||..|.::|
Zfish   368 KALCESCDIGPTLISVVTWLGYVNSAVNPIIYTAFNVEFRNVFHKLL 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 69/197 (35%)
TM helix 1 228..254 CDD:320454 8/26 (31%)
TM helix 2 261..287 CDD:320454 14/25 (56%)
TM helix 3 299..329 CDD:320454 18/30 (60%)
TM helix 4 340..362 CDD:320454 4/21 (19%)
TM helix 5 383..412 CDD:320454 11/34 (32%)
7tm_GPCRs <743..816 CDD:475119 36/72 (50%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 12/24 (50%)
drd4-rsNP_001012638.3 7tmA_D4_dopamine_R 19..410 CDD:320434 149/609 (24%)
TM helix 1 20..46 CDD:320434 9/31 (29%)
TM helix 2 53..79 CDD:320434 14/25 (56%)
TM helix 3 92..122 CDD:320434 18/29 (62%)
TM helix 4 134..157 CDD:320434 4/22 (18%)
TM helix 5 173..202 CDD:320434 10/28 (36%)
TM helix 6 338..368 CDD:320434 15/47 (32%)
TM helix 7 378..403 CDD:320434 12/24 (50%)

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