DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and Oct-TyrR

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	216/786 - (27%)
Similarity:	321/786 - (40%)	Gaps:	246/786 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PPTD----VNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPA 152
            |..|    ||.|||     :|.|||.||||.::                       |.|.:.:.|
  Fly     2 PSADQILFVNVTTT-----VAAAALTAAAAVST-----------------------TKSGSGNAA 38

  Fly   153 LQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVA- 216
            ....|.|::     .|:|.                  |.:||.||.|     ..||...|:.::
  Fly    39 RGYTDSDDD-----AGMGT------------------EAVANISGSL-----VEGLTTVTAALST 75

  Fly   217 -----------EDDFTQL------LRMAV-------TSVLLGLMILVTIIGNVFVIAAIILERNL 257
                       |....:|      |::||       |:::|.::|::|||||:.||.::...:.|
  Fly    76 AQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPL 140

  Fly   258 QNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAV 322
            :.|.|:.:.|||||||.||.||:|....|.|...|..|..||.:|.:|||||||:|||:|.|||:
  Fly   141 RIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIAL 205

  Fly   323 DRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKD-PDYLQRIEQQKCMVSQDVS 385
            |||||:|: |:|...||..||.::|..||..::::|..|..||.| ||  :......|.::....
  Fly   206 DRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPD--EFTSATPCELTSQRG 268

  Fly   386 YQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLR 450
            |.::::..:|::||.::..:|.:|:...|:|:..|                  |...||:.:.|:
  Fly   269 YVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRER------------------ARANKLNTIALK 315

  Fly   451 LGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNT---VEDTEFSSSNV---DSKSRAGV 509
            ........:.:..|...||..|...|..|..|.......|   ..|.|..||..   ...|:||
  Fly   316 STELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAG- 379

  Fly   510 EAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPE-HGEQEDREELEDQ 573
                ..||......|:|.|.|:..::..|.|.. :|....||:.......| ||||:
  Fly   380 ----PHGNSDPQQQHVVVLVKKSRRAKTKDSIK-HGKTRGGRKSQSSSTCEPHGEQQ-------- 431

  Fly   574 DEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTS 638
                         .:.|.|...|   |:..|                        ...|||.|.:
  Fly   432 -------------LLPAGGDGGS---CQPGG------------------------GHSGGGKSDA 456

  Fly   639 NATT-------------------ITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHP 684
            ..:|                   .||:....||:.|    |:||.:..|:..|||.:
  Fly   457 EISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSST----GVAAVSVTPLQKKTSGV-------- 509

  Fly   685 LCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKA 749
                                          :|..:::|::|                 ..:||:|
  Fly   510 ------------------------------NQFIEEKQKIS-----------------LSKERRA 527

  Fly   750 AKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQ 814
            |:||.||.|.||:||||||:|.:.:|.|..|..::...:...||||.||.|||||||||:.::|:
  Fly   528 ARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRR 592

  Fly   815 AFKRIL 820
            ||||:|
  Fly   593 AFKRLL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	77/194 (40%)
		TM helix 1	228..254	CDD:320454	11/32 (34%)
		TM helix 2	261..287	CDD:320454	13/25 (52%)
		TM helix 3	299..329	CDD:320454	21/29 (72%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	6/28 (21%)
		7tm_GPCRs	<743..816	CDD:355774	37/72 (51%)
		TM helix 6	747..772	CDD:341315	17/24 (71%)
		TM helix 7	784..809	CDD:341315	14/24 (58%)
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	61/130 (47%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	68/168 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2699
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.760