DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and 5-HT2B

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	917	Identity:	227/917 - (24%)
Similarity:	340/917 - (37%)	Gaps:	290/917 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 NVAVGLGAMLLNDT-----------LLLEGNDSSLFGEMLANRSGQLDLI--NGTGGLNVTTSKV 215
            :|...|||  .||:           :|.|.:::........:|..||.:.  |.||  |.|.|..
  Fly     4 DVYASLGA--YNDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATG--NATISAT 64

  Fly   216 AED------DFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLF 274
            .||      ::..||.:        :::|.|..||:.|..||..||.||||.||.:.|||:.||.
  Fly    65 FEDVPFDANNYWALLAL--------VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLM 121

  Fly   275 VACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRT 338
            ||.||||||.:..:...:.||.|.|..|...|||.|||||:||..|:||||.::. .:.:..::|
  Fly   122 VAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKT 186

  Fly   339 SNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVIL 403
            ..||.:.|..||..::.:|| |.......::...:....|.:...| |::..:...||:||.|:|
  Fly   187 RRRVTLKIVFVWLLSIAMSL-PLSLMYSKNHASVLVNGTCQIPDPV-YKLVGSIVCFYIPLGVML 249

  Fly   404 ALY-WKIYQTARKR--------------------------IHRR-------RPRPVDAA------ 428
            ..| ..:...||:|                          :.||       :|.|.:|:
  Fly   250 LTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAH 314

  Fly   429 -----------VNNNQ---PDGG-----AATDTKLHRL---RLRLGR-------FSTAKSKTGSA 464
                       ::|::   ||..     ..|.|.||:.   .|:|.|       .||..|.|.|.
  Fly   315 SANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSE 379

  Fly   465 VGVSG------PAS----------------------------------GGRALGLVDGNSTNTVN 489
            ..:|.      |:|                                  |...|||    ||.|:.
  Fly   380 FSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGL----STTTLG 440

  Fly   490 TVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQED 554
            ...:   |:.|..:.||.|.|....:.:|::  ..|.|..|::     ::|:||.|.......||
  Fly   441 IERE---STRNSLASSRMGGEQSDGTLSQLS--QRLRAYKKRR-----RASSAVPGREKRAGHED 495

  Fly   555 ---DGQRP--------EHGE-------------QEDREELEDQDEQVGPQPTTATSAMTA----- 590
               |.:.|        .|..             ||..::.:|::|:...|....|.:...
  Fly   496 ADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTE 560

  Fly   591 ------------AGTNESEDQCKANGV---EVLEDPQLQQQLEQVQ------------------- 621
                        ||.|...|..:...|   ....|..||..::..:
  Fly   561 LDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSS 625

  Fly   622 ----------------QLQKSVKSGGGGGASTSNATTITSISALSPQ---------TPTSQGVGI 661
                            .|..||.:|..||.:.:...|:.  |.|||.         |..|.|.|.
  Fly   626 SPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVG--STLSPHSAHNQGSSLTVQSDGSGY 688

  Fly   662 AAAAAGP-------MTAKTSTLTSCNQSH------------------PLCGTANESPSTPEPRSR 701
            .||...|       ..:||:::.:.:.|.                  |.......:.|||..||.
  Fly   689 LAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSA 753

  Fly   702 QPTTPQQQPHQQAHQ-------------QQQQQQQLSSIANPMQKVNKRKETLEA---KRERKAA 750
            ...:.|...:|.|.:             ..|:||.:.|..:....|..|..:...   :.|:||.
  Fly   754 TLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKAT 818

  Fly   751 KTLAIITGAFVVCWLPFFVMALTMPLCAACQ--ISDSVASLFLWLGYFNSTLNPVIYTIFSPEFR 813
            |.|.::...||:.|.||||:.|...:||.|:  ||..|..:..||||.:|.:||:.||||:..||
  Fly   819 KVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFR 883

  Fly   814 QAFKRIL 820
            ||||::|
  Fly   884 QAFKKVL 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/187 (36%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	8/21 (38%)
		TM helix 5	383..412	CDD:320454	9/29 (31%)
		7tm_GPCRs	<743..816	CDD:355774	33/77 (43%)
		TM helix 6	747..772	CDD:341315	11/24 (46%)
		TM helix 7	784..809	CDD:341315	11/24 (46%)
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	66/173 (38%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	58/149 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010