DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and mAChR-B

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	1006	Identity:	197/1006 - (19%)
Similarity:	327/1006 - (32%)	Gaps:	363/1006 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 AARITAKAAHRALTTKQDATSSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFG 189
            ||:|..:::        |..|.|.:.......:.|.|.||:            ||...|.||..|
  Fly    64 AAKIYGESS--------DFNSWPVNEQLQWYRNFDVNNTNL------------LLAVRNQSSDGG 108

  Fly   190 EMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILE 254
            ..::..|...::      |.......|      |.:..:.::.|.:.|::|:.||:.|:.|.|::
  Fly   109 STMSGSSSDSEI------LGPVLPPFA------LWQTILIAICLAICIILTVGGNILVLLAFIVD 161

  Fly   255 RNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVA 319
            ||::..:||.:||||..|:.:..:.||...:|.:...|.|||.|||:|.|.|...|..|...::.
  Fly   162 RNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLL 226

  Fly   320 IAVDRYWAV-TNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQD 383
            |.:|||.:| ....|...||..||..|:...|....::.....|||:.....:.:...:|.| |.
  Fly   227 ITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAV-QF 290

  Fly   384 VSYQVFATCCT---FYVPLLVILALYWKIYQTA-----RKRIHRRRPRPVDA------------- 427
            :...:|.|...   ::..|:|:..||..||:||     |....:|:.:.:.|
  Fly   291 LKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHA 355

  Fly   428 ---------------AVNNNQPDGGAATDTKLHRL------------------------RLRLGR 453
                           .:..:|.|..:|..|.:.||                        |....:
  Fly   356 AGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAK 420

  Fly   454 FSTAKSKTGSAVGV------SGPASGGRALGLVDGNSTNTVNTVED--TEFSSSNVDSKSRAGVE 510
            ......|..:||..      |.||        .|.:..::||..:.  |:...:|:..:|..|:
  Fly   421 IQEEAKKREAAVDAEKSERSSSPA--------FDSDEESSVNQAQQLITQQKLNNMRKRSSIGL- 476

  Fly   511 APSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQ-----EDREEL 570
               ..|.|       .||...:||...:.|...:....:..|....|:..|.:.     :.:||:
  Fly   477 ---VFGAQ-------AALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEM 531

  Fly   571 ED------------QDEQVGPQP------TTATSAM----------------TAAGTNESEDQCK 601
            ..            |..|..|.|      .|:.|.:                |...|::......
  Fly   532 RSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVD 596

  Fly   602 ANGVEVLEDPQLQQQLEQV-----------------------------------------QQLQK 625
            ...:||..| |:.|.|.|.                                         .:|:.
  Fly   597 LAPIEVPSD-QVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRY 660

  Fly   626 SVKSGGGGGASTSNATTITSIS------ALSP------------------QTPT----------- 655
            ..:|.....:.|:|:||..:.|      .|.|                  |||:
  Fly   661 MDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSL 725

  Fly   656 ----------SQGVGIAAA--------------------------------------------AA 666
                      ||.:..|.|                                            |:
  Fly   726 NLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRAS 790

  Fly   667 GPM--TAKTSTLTSCNQSHPLCGTANES-PSTPEPRSRQPTTPQQQPHQQAHQQQ---------- 718
            .||  ::|.:.|.|.....||......| |.|..|:|....|| ..|.::..:::
  Fly   791 SPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTP-PVPLERIEERETSDSNTNKMP 854

  Fly   719 ----------------------------------QQQQQLSSIANPMQK---------------- 733
                                              ::::.|::..|..::
  Fly   855 STSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKAL 919

  Fly   734 -----VNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLC--AACQISDSVASLFL 791
                 |..|:::....|.|||.:|::.|.|.||.||.|:.|:||....|  ..| |::.:.....
  Fly   920 PLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPC-INEHLYMFSY 983

  Fly   792 WLGYFNSTLNPVIYTIFSPEFRQAFKRILFG 822
            :|.|.||.:||..|.:.:.:|::.|.|||.|
  Fly   984 FLCYANSPMNPFCYALANQQFKKTFTRILKG 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	58/189 (31%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	9/25 (36%)
		TM helix 3	299..329	CDD:320454	12/30 (40%)
		TM helix 4	340..362	CDD:320454	4/21 (19%)
		TM helix 5	383..412	CDD:320454	8/31 (26%)
		7tm_GPCRs	<743..816	CDD:355774	26/74 (35%)
		TM helix 6	747..772	CDD:341315	12/24 (50%)
		TM helix 7	784..809	CDD:341315	7/24 (29%)
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	59/191 (31%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	58/186 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010