DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and 5-HT2A

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_730859.1	Gene:	5-HT2A / 40575	FlyBaseID:	FBgn0087012	Length:	930	Species:	Drosophila melanogaster

Alignment Length:	943	Identity:	226/943 - (23%)
Similarity:	353/943 - (37%)	Gaps:	279/943 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PPTDVNTTTTTAGSPLATAALAAAAASASVAAAAAR------------------ITAKAAHRALT 138
            |.|..:.|.|      ||||:|:|:||.:.|....|                  |..:.:|
  Fly    11 PSTGTSETAT------ATAAVASASASDTAATFTLRHFNCRLEEADWPGPRQPFIDCEGSH---- 65

  Fly   139 TKQDATS-SPASSP-ALQLIDMDNN---------------------------------------- 161
              .::|| :|:|.| :..||:..||
  Fly    66 --TNSTSYTPSSLPTSKNLIEGPNNTFQCARQAIDEAEHNAFYSCDGESPLSENCTLRLKARLLR 128

  Fly   162 -----YTNVAVGL--------------------GAMLL-------NDTLL-----LE-------- 181
                 |.::.:.:                    |.|:|       ::.||     ||
  Fly   129 WPYEAYEHIRLAINGALSDYASDKLSDSSSCDEGGMVLQCKLGQAHELLLCHLQQLEREPLREVG 193

  Fly   182 ------GNDSSL-------------------FGEMLANRSGQLDLINGTG-----------GLNV 210
                  .|||.|                   ..|::....|.|.::|.|.           .||.
  Fly   194 SAEESFSNDSLLQAFQIELGAERDGLWSFLNLSELMEPDHGFLGIMNVTNTSLDMFLPNLTALNT 258

  Fly   211 TTSKVAEDDFTQLLRMAVTSVLLG--------LMILVTI------IGNVFVIAAIILERNLQNVA 261
            |::....|..|:   .|||...|.        |.:.|..      :||:.|..|:.|:|.||||.
  Fly   259 TSTASTADMATE---FAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVT 320

  Fly   262 NYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYW 326
            ||.:.|||:|||.|:..|||:||:......|.||...|:|:.:||||.|::||||:..|::.||.
  Fly   321 NYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYM 385

  Fly   327 AVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDV------ 384
            .:.| :...|..|.....:.|..||..|::||       .....|..:.::..|...::
  Fly   386 GIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS-------SSITVLGLVNEKNIMPEPNICVINNR 443

  Fly   385 SYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRL 449
            ::.||.:...||:|:|:::..|.......||:.......|                :::|.|
  Fly   444 AFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHP----------------ESELFR--- 489

  Fly   450 RL-GRFSTAKSKTGSAVGVSGPASG--GRALGLVDGN-STNTVNTVEDTEFSS--SNVDSKSRAG 508
            || |||:.....:...:.:....||  .:.|.:.||| :.||...:|:....|  |.|:...|..
  Fly   490 RLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPL 554

  Fly   509 VEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQ 573
            ::..:.|...:.|||....:....|  .|.|.....|.|.|..:........|...
  Fly   555 MQQRTASSRSMGTVSFRNVVNGTSG--AAGSGRRTTGTAHSSFRFSGAGIFRHSSS--------- 608

  Fly   574 DEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLED----------------PQLQQQLE-QVQ 621
                    :.|:|..:.:.:..|....|..|...|.|                |..:..:. .:.
  Fly   609 --------SPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTIS 665

  Fly   622 QLQKSVKSG-GGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTS--CNQSH 683
            |.|....:. ||.|..|..||.:.:....|....||.     ::..|....|.:|:..  .|||.
  Fly   666 QPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSN-----SSLGGTSLMKIATIQGPILNQSQ 725

  Fly   684 PLCGTANESPSTPEPRSRQPTTPQQ---QPHQQAHQQQQQQQQLSSIANP---MQKVNKR--KET 740
            ...|  |......:|.:.:|..||:   :|.:.|         .:.:|.|   ::.:|.|  :.:
  Fly   726 AAGG--NHMVQKVKPTALKPEEPQRNKVRPFKFA---------FNRVATPTLNLRFLNNRSKRNS 779

  Fly   741 LEAK---RERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNP 802
            |.|.   .|:||.|.|.::...||:||.|||::.:....|..||:.:.|.:..|||||.:||:||
  Fly   780 LSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINP 844

  Fly   803 VIYTIFSPEFRQAFKRIL----FGGHRPVHYRS 831
            :|||||:..||.||.|:|    ....||:.|||
  Fly   845 IIYTIFNRTFRAAFIRLLKCNCKRSGRPLRYRS 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	65/206 (32%)
		TM helix 1	228..254	CDD:320454	9/39 (23%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	14/29 (48%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	7/34 (21%)
		7tm_GPCRs	<743..816	CDD:355774	33/75 (44%)
		TM helix 6	747..772	CDD:341315	11/24 (46%)
		TM helix 7	784..809	CDD:341315	14/24 (58%)
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	51/135 (38%)
5-HT2A	NP_730859.1	7tm_1	302..>477	CDD:278431	61/181 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940