Protein Alignment 5-HT1A and mAChR-A

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Alignment Length: 861
• Identity: 208/861 - (24%)
• Similarity: 324/861 - (37%)
• Gaps: 222/861 - (25%)

  Fly   106 PLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPALQLIDMDNNYTNVAVGLG 170
            |:.:.||||....:.:......:|....  ..||...:|::..:|||    .....|.      |
  Fly     3 PVMSLALAAHGPPSILEPLFKTVTTSTT--TTTTTTTSTTTTTASPA----GYSPGYP------G 55

  Fly   171 AMLLNDTLLLEGNDSSLFGEMLANRSGQL-DLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLG 234
            ..||  |.|.|...|:....:....||.. :..|||.|......:.:      |..|.|...:..
  Fly    56 TTLL--TALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYS------LASMVVMGFVAA 112

  Fly   235 LMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELC 299
            ::..||:.|||.|:.:..:::.||.::||.:.|||:||..:..:.|||.||..|...|.|||.:|
  Fly   113 ILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVC 177

  Fly   300 DIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFG 363
            |.|.:.|.|...||:|:|:.|:.|||::||. :.|...||:||..:||...|..::::.....:.
  Fly   178 DTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYS 242

  Fly   364 W----------KDPDYLQRIEQQKCMVSQDVSYQVFATC-CTFYVPLLVILALYWKIYQTARKRI 417
            |          ||..|:|.||..:        |..|.|. ..||.|:.::..|||:|::..:|
  Fly   243 WPYIEGKRTVPKDECYIQFIETNQ--------YITFGTALAAFYFPVTIMCFLYWRIWRETKK-- 297

  Fly   418 HRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAK-SKTGSAVGVSGPASGG-RALGLV 480
             |::..|                       .|:.|:..::| |.:.....|...|||| .|...|
  Fly   298 -RQKDLP-----------------------NLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQV 338

  Fly   481 DGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKS--TAKSSAAV 543
            .||..:|.....    |.|:.|::|.........||      .|.:...|...||  |.|.|...
  Fly   339 GGNDHDTWRRPR----SESSPDAESVYMTNMVIDSG------YHGMHSRKSSIKSTNTIKKSYTC 393

  Fly   544 NGMAP--------SGRQEDDGQRPEHGEQEDREELEDQDEQVG-PQPTT-----ATSAMTAAGTN 594
            .|...        |||::.|....|..|..|          :| ..|.|     .:|.......|
  Fly   394 FGSIKEWCIAWWHSGREDSDDFAYEQEEPSD----------LGYATPVTIETPLQSSVSRCTSMN 448

  Fly   595 ESEDQCKANG------------VEVLEDPQLQQQLEQVQQLQKSV-----------KSGGGGGA- 635
            ...|.....|            .:|...|..:..|..:.|||:..           .||.|.||
  Fly   449 VMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAI 513

  Fly   636 ----------------------------STSNAT-----TITSISALSPQTPTSQ---------- 657
                                        :|.|||     |:..|:.::.::.:..
  Fly   514 NNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLP 578

  Fly   658 --------------GVGIAAAAAGPMTAKTSTLTSCNQSH---PLCGTANESPSTPEPRSRQPTT 705
                          |.|..|||:..::.:.....|....|   |.. ||..:|......:|:|..
  Fly   579 SDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTT-TAAAAPLASAAATRRPLP 642

  Fly   706 PQQQP------HQQAHQQQQQQ--------QQLS---------------SIANPMQKVNKRKETL 741
            .:...      .:.:|.|...:        :||.               ::.|......|:|::.
  Fly   643 SRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQ 707

  Fly   742 EAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPL--CAACQISDSVASLFLWLGYFNSTLNPVI 804
            |.::|.||||||:.|..:|::.|.|:.::.|..||  |:.| |...:...|..|.|.|||:||:.
  Fly   708 EKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDC-IPTELWDFFYALCYINSTINPMC 771

  Fly   805 YTIFSPEFRQAFKRIL 820
            |.:.:..||:.:.|||
  Fly   772 YALCNATFRRTYVRIL 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	66/197 (34%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	13/29 (45%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	10/29 (34%)
		7tm_GPCRs	<743..816	CDD:475119	28/74 (38%)
		TM helix 6	750..772	CDD:410628	8/21 (38%)
		TM helix 7	784..809	CDD:410628	9/24 (38%)
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	68/205 (33%)
		TM helix 1	106..132	CDD:320428	7/25 (28%)
		TM helix 2	139..165	CDD:320428	12/25 (48%)
		TM helix 3	177..207	CDD:320428	13/29 (45%)
		TM helix 4	219..242	CDD:320428	5/22 (23%)
		TM helix 5	265..294	CDD:320428	10/36 (28%)
		7tm_GPCRs	<707..783	CDD:475119	29/76 (38%)
		TM helix 6	716..738	CDD:410628	8/21 (38%)
		TM helix 7	751..776	CDD:410628	9/24 (38%)