DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and drd2b

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_922918.1 Gene:drd2b / 378719 ZFINID:ZDB-GENE-030910-2 Length:452 Species:Danio rerio


Alignment Length:625 Identity:165/625 - (26%)
Similarity:241/625 - (38%) Gaps:197/625 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 NGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 267
            ||||.||.|..: |:..:...      ::||.|:|.|.:.|||.|..|:..|:.||...|||:.|
Zfish    16 NGTGALNCTGCE-AKHQYNYY------AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVS 73

  Fly   268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNID 332
            ||||||.||.||||.....|:...|......|||:.:.||:.||||||:|.||::|||.||....
Zfish    74 LAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPM 138

  Fly   333 YIHSRTSN--RVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTF 395
            ..::|.|:  ||.:||..||..:..:|....||..:   ....:...|.:: :.::.|:::..:|
Zfish   139 LYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNN---TATRDGSVCEIA-NPAFVVYSSIMSF 199

  Fly   396 YVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTK---LHRLRLRLGRFSTA 457
            |||.::.|.:|.:||...|||  |:|   |:...:..:.|..|....|   .|...::|   .|.
Zfish   200 YVPFIITLLVYVQIYVVLRKR--RKR---VNTKRSCQKTDADAQPPLKEKCTHPEDVKL---CTV 256

  Fly   458 KSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATV 522
            ..||...|    ||...:|            ..:::......:|..:..||...|.         
Zfish   257 IIKTNGGV----PAKNKKA------------QLIKEVLHQGGDVGMEMVAGTSPPE--------- 296

  Fly   523 SHLVALAKQQGKSTAKSSAAVNGMA--PSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTAT 585
                       |....||..|:.:|  ||         |.||.....|...:.||:.|    .|.
Zfish   297 -----------KKKLASSLVVDLLATPPS---------PNHGSPSHAEYQSNGDEKNG----HAK 337

  Fly   586 SAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALS 650
            ...:...|...|.|...||                                 ...||:|      
Zfish   338 DVQSPKETKPVETQALPNG---------------------------------KTRTTVT------ 363

  Fly   651 PQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAH 715
                                 ||                                          
Zfish   364 ---------------------KT------------------------------------------ 365

  Fly   716 QQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAAC 780
                              ::|||  :...:|:||.:.|||:.|.|::||||||:..:....|.:|
Zfish   366 ------------------MSKRK--MSQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSC 410

  Fly   781 QISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            .:...:.:.|.||||.||.:||:|||.|:.|||:||.:||
Zfish   411 VVPLEMYNAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKIL 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 71/187 (38%)
TM helix 1 228..254 CDD:320454 10/25 (40%)
TM helix 2 261..287 CDD:320454 16/25 (64%)
TM helix 3 299..329 CDD:320454 18/29 (62%)
TM helix 4 340..362 CDD:320454 7/23 (30%)
TM helix 5 383..412 CDD:320454 9/28 (32%)
7tm_GPCRs <743..816 CDD:475119 32/72 (44%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 12/24 (50%)
drd2bNP_922918.1 7tm_GPCRs 33..446 CDD:475119 153/601 (25%)
TM helix 1 35..59 CDD:410628 10/29 (34%)
TM helix 2 68..90 CDD:410628 16/21 (76%)
TM helix 3 106..128 CDD:410628 13/21 (62%)
TM helix 4 152..168 CDD:410628 5/15 (33%)
TM helix 5 188..211 CDD:410628 6/22 (27%)
TM helix 6 380..402 CDD:410628 11/21 (52%)
TM helix 7 414..439 CDD:410628 12/24 (50%)

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