Protein Alignment 5-HT1A and htr5ab

DIOPT Version :9

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001007122.1
• Gene: htr5ab / 368475
• ZFINID: ZDB-GENE-030616-574
• Length: 346
• Species: Danio rerio
• Alignment Length: 603
• Identity: 141/603 - (23%)
• Similarity: 203/603 - (33%)
• Gaps: 293/603 - (48%)

  Fly   228 VTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI-SQG 291
            :|..||.::::.|.:.|:.|:..|:..|....|.:.||||:|::|:.||.|||||..|.|: .:.
Zfish    32 LTLTLLAMLVVATFVWNLLVLVTILRVRTFHRVPHNLVASMAISDVMVAGLVMPLSLVRELYGRR 96

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDY---IHSRTSNRVFMMIFCVWTA 352
            ||||..||.:|.|||||||||||.::.|||:||||::| :::|   ...|.||   :||...|..
Zfish    97 WILGRALCQVWISCDVLCCTASIWNVTAIALDRYWSITRHLEYTLKTRKRISN---VMIGLTWLL 158

  Fly   353 AVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRI 417
            :.::||:|.|||.: .|.:  :...|.|||:.||.||:|...||:||.|:|.:|||||:.|:.||
Zfish   159 SSVISLSPLFGWGE-TYSE--DSLACQVSQEPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAKFRI 220

  Fly   418 HRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDG 482
            ..|:
Zfish   221 GSRK------------------------------------------------------------- 224

  Fly   483 NSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMA 547
              |||:..:
Zfish   225 --TNTITPM-------------------------------------------------------- 231

  Fly   548 PSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQ 612
                                                                  |..:||.|..:
Zfish   232 ------------------------------------------------------AEVIEVKEAER 242

  Fly   613 LQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLT 677
            ..|....|:....|.::.|
Zfish   243 QPQMAFTVRHATVSFQTDG---------------------------------------------- 261

  Fly   678 SCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLE 742
                                                                         ||..
Zfish   262 -------------------------------------------------------------ETWR 265

  Fly   743 AKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTI 807
            .::||:||..:.|:.|.||:||:|||:..|.:||| :|.|.....|:||||||.||..||:|||.
Zfish   266 EQKERRAALMVGILIGVFVLCWIPFFLAELIIPLC-SCDIPPVWKSVFLWLGYSNSFFNPLIYTA 329

  Fly   808 FSPEFRQAFKRILFGGHR 825
            |:..:..|| |.||...|
Zfish   330 FNKNYNNAF-RNLFSRQR 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	84/189 (44%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	20/29 (69%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	16/28 (57%)
		7tm_GPCRs	<743..816	CDD:355774	34/72 (47%)
		TM helix 6	747..772	CDD:341315	12/24 (50%)
		TM helix 7	784..809	CDD:341315	14/24 (58%)
htr5ab	NP_001007122.1	7tm_1	47..327	CDD:278431	127/566 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010