DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and HTR6

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000862.1 Gene:HTR6 / 3362 HGNCID:5301 Length:440 Species:Homo sapiens


Alignment Length:593 Identity:105/593 - (17%)
Similarity:165/593 - (27%) Gaps:295/593 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly   233 LGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPE 297
            |.::|.:|...|..:||.|..:..|:|.:|:.:.||..:||.|..:|||...:..:...|:|...
Human    33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARG 97

  Fly   298 LCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAP- 360
            ||.:||:.||:||:||||:|..|::|||..:.: :.|....|..|...::...|:.|.:.|..| 
Human    98 LCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPL 162

  Fly   361 QFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPV 425
            ..||.:..:.:.....:|.:...:.:.:.|:..||::|...|...|.:|...|||          
Human   163 LLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARK---------- 217

  Fly   426 DAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNT 490
                                                                             
Human   218 ----------------------------------------------------------------- 217

  Fly   491 VEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDD 555
                                                                             
Human   218 ----------------------------------------------------------------- 217

  Fly   556 GQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQV 620
                                                                             
Human   218 ----------------------------------------------------------------- 217

  Fly   621 QQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPL 685
                                                |.|.:|:...|..:..:.||         
Human   218 ------------------------------------QAVQVASLTTGMASQASETL--------- 237

  Fly   686 CGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAA 750
                 :.|.||.|                               .::..:.|:  |..|..|||.
Human   238 -----QVPRTPRP-------------------------------GVESADSRR--LATKHSRKAL 264

  Fly   751 K---TLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEF 812
            |   ||.|:.|.|.|.||||||..:...:|..  ||..:..:..||||.|||:||:||.:|..:|
Human   265 KASLTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDF 327

  Fly   813 RQAFKRIL 820
            ::|..|.|
Human   328 KRALGRFL 335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 54/181 (30%)
TM helix 1 228..254 CDD:320454 7/20 (35%)
TM helix 2 261..287 CDD:320454 9/25 (36%)
TM helix 3 299..329 CDD:320454 16/29 (55%)
TM helix 4 340..362 CDD:320454 5/22 (23%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 33/75 (44%)
TM helix 6 750..772 CDD:410628 13/24 (54%)
TM helix 7 784..809 CDD:410628 11/24 (46%)
HTR6NP_000862.1 7tmA_5-HT6 27..331 CDD:320182 102/587 (17%)
TM helix 1 28..54 CDD:320182 7/20 (35%)
TM helix 2 61..87 CDD:320182 9/25 (36%)
TM helix 3 99..129 CDD:320182 16/29 (55%)
TM helix 4 141..164 CDD:320182 5/22 (23%)
TM helix 5 185..214 CDD:320182 7/28 (25%)
TM helix 6 261..291 CDD:320182 16/29 (55%)
TM helix 7 299..324 CDD:320182 11/24 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..392
Blue background indicates that the domain is not in the aligned region.

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