Protein Alignment 5-HT1A and HTR2C

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 113/596 - (18%)
• Similarity: 194/596 - (32%)
• Gaps: 284/596 - (47%)

  Fly   235 LMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP---LGAVYEISQGWILGP 296
            ::|::||.||:.||.|:.:|:.|.|..||.:.|||:||:.|..||||   |..:|:..  |.|..
Human    62 IIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV--WPLPR 124

  Fly   297 ELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNR--VFMMIFCVWTAAVIVSL 358
            .||.:|.|.|||..||||:||.||::|||.|:.| |:  |||.::|  ..|.|..||..::.||:
Human   125 YLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIE--HSRFNSRTKAIMKIAIVWAISIGVSV 187

  Fly   359 -APQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRP 422
             .|..|.:|.:.: .:....|::: |.::.:..:...|::||.:::..|.......|:
Human   188 PIPVIGLRDEEKV-FVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRR------- 243

  Fly   423 RPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNT 487
                                                                :||.|:
Human   244 ----------------------------------------------------QALMLL------- 249

  Fly   488 VNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQ 552
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   553 EDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQL 617
                    ||..|:             .|..:...:.....|.:|::..||
Human   250 --------HGHTEE-------------PPGLSLDFLKCCKRNTAEEENSAN-------------- 279

  Fly   618 EQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQS 682
                                                                             
Human   280 ----------------------------------------------------------------- 279

  Fly   683 HPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRER 747
                                   |.|..:.:..::::::.:     ..||.:|         .||
Human   280 -----------------------PNQDQNARRRKKKERRPR-----GTMQAIN---------NER 307

  Fly   748 KAAKTLAIITGAFVVCWLPFFVMALTMPLC-AAC--QISDSVASLFLWLGYFNSTLNPVIYTIFS 809
            ||:|.|.|:...|::.|.|||:..:...|| .:|  ::.:.:.::|:|:||..|.:||::||:|:
Human   308 KASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFN 372

  Fly   810 PEFRQAFKRIL 820
            ..:|:||...|
Human   373 KIYRRAFSNYL 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/184 (36%)
		TM helix 1	228..254	CDD:320454	8/18 (44%)
		TM helix 2	261..287	CDD:320454	13/28 (46%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	8/24 (33%)
		TM helix 5	383..412	CDD:320454	5/28 (18%)
		7tm_GPCRs	<743..816	CDD:475119	26/75 (35%)
		TM helix 6	750..772	CDD:410628	8/21 (38%)
		TM helix 7	784..809	CDD:410628	9/24 (38%)
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	113/596 (19%)
		TM helix 1	55..81	CDD:341346	8/18 (44%)
		TM helix 2	88..114	CDD:341346	13/25 (52%)
		TM helix 3	127..157	CDD:341346	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	7/22 (32%)
		TM helix 5	211..240	CDD:341346	5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		4/133 (3%)
		TM helix 6	304..334	CDD:341346	13/38 (34%)
		TM helix 7	347..372	CDD:341346	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458