DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and HTR2A

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000612.1 Gene:HTR2A / 3356 HGNCID:5293 Length:471 Species:Homo sapiens


Alignment Length:703 Identity:144/703 - (20%)
Similarity:225/703 - (32%) Gaps:317/703 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 MLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGT----GGLNVTTSKVAEDDFTQLLRMAV---T 229
            |.|||...|..||   |....||.|   |..|.|    ...|::...........||.:..   :
Human    19 MQLNDDTRLYSND---FNSGEANTS---DAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWS 77

  Fly   230 SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG--W 292
            ::|..::|::||.||:.||.|:.||:.|||..||.:.|||:||:.:..||||: ::..|..|  |
Human    78 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV-SMLTILYGYRW 141

  Fly   293 ILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNR--VFMMIFCVWTAAVI 355
            .|..:||.:|...|||..||||:||.||::|||.|:.|..: |||.::|  .|:.|..|||.:|.
Human   142 PLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIH-HSRFNSRTKAFLKIIAVWTISVG 205

  Fly   356 VSL-APQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHR 419
            :|: .|.||.:|...:  .::..|:::.| ::.:..:..:|::||.:::..|             
Human   206 ISMPIPVFGLQDDSKV--FKEGSCLLADD-NFVLIGSFVSFFIPLTIMVITY------------- 254

  Fly   420 RRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNS 484
                                              |.|.||                         
Human   255 ----------------------------------FLTIKS------------------------- 260

  Fly   485 TNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPS 549
                                                       |.|:                  
Human   261 -------------------------------------------LQKE------------------ 264

  Fly   550 GRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQ 614
                                              ||..::..||     :.|......|.    |
Human   265 ----------------------------------ATLCVSDLGT-----RAKLASFSFLP----Q 286

  Fly   615 QQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSC 679
            ..|...:..|:|:....|   |.:...|:.|||                                
Human   287 SSLSSEKLFQRSIHREPG---SYTGRRTMQSIS-------------------------------- 316

  Fly   680 NQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK 744
                                                                             
Human   317 ----------------------------------------------------------------- 316

  Fly   745 RERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASL---FLWLGYFNSTLNPVIYT 806
            .|:||.|.|.|:...|||.|.|||:..:...:|......|.:.:|   |:|:||.:|.:||::||
Human   317 NEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYT 381

  Fly   807 IFSPEFRQAFKR---------------ILFGGHRPVHYRSGKLXIVHAKRRRR 844
            :|:..:|.||.|               ||......:.|:|.:|.:...|..::
Human   382 LFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQ 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 69/193 (36%)
TM helix 1 228..254 CDD:320454 9/28 (32%)
TM helix 2 261..287 CDD:320454 11/25 (44%)
TM helix 3 299..329 CDD:320454 17/29 (59%)
TM helix 4 340..362 CDD:320454 9/24 (38%)
TM helix 5 383..412 CDD:320454 5/28 (18%)
7tm_GPCRs <743..816 CDD:475119 27/75 (36%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 11/27 (41%)
HTR2ANP_000612.1 7tmA_5-HT2A 75..391 CDD:341345 118/596 (20%)
TM helix 1 76..102 CDD:341345 9/25 (36%)
TM helix 2 109..135 CDD:341345 11/26 (42%)
TM helix 3 148..178 CDD:341345 17/29 (59%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 8/22 (36%)
TM helix 5 231..260 CDD:341345 7/76 (9%)
TM helix 6 316..346 CDD:341345 14/126 (11%)
TM helix 7 359..384 CDD:341345 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..471
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405 469..471
Blue background indicates that the domain is not in the aligned region.

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