DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and HTR1E

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000856.1 Gene:HTR1E / 3354 HGNCID:5291 Length:365 Species:Homo sapiens


Alignment Length:598 Identity:143/598 - (23%)
Similarity:208/598 - (34%) Gaps:262/598 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   225 RMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEIS 289
            :|.:...|:.:..|.|:: |:.||.||...:.|...||||:.||||.||.||.|||||..:|.:.
Human    22 KMLICMTLVVITTLTTLL-NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVM 85

  Fly   290 QGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAA 353
            ..|.||..||::|.|.|:.|||.|||||..||:|||||:|| |:|...||:.|..:||..|||.:
Human    86 DRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTIS 150

  Fly   354 VIVSLAPQFGWKDPDYLQRIEQQKCMVSQD-VSYQVFATCCTFYVPLLVILALYWKIYQTARKRI 417
            :.:|:.|.| |:....|.....| |.:..| |.|.:::|...||:||.:||.||::||..| |.:
Human   151 IFISMPPLF-WRSHRRLSPPPSQ-CTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAA-KSL 212

  Fly   418 HRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDG 482
            :::|                                                            |
Human   213 YQKR------------------------------------------------------------G 217

  Fly   483 NSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMA 547
            :|.:..|...|::                     |..|:                          
Human   218 SSRHLSNRSTDSQ---------------------NSFAS-------------------------- 235

  Fly   548 PSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQ 612
                                                                ||           
Human   236 ----------------------------------------------------CK----------- 237

  Fly   613 LQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLT 677
                                       .|....:|..|...||::.....|:...|         
Human   238 ---------------------------LTQTFCVSDFSTSDPTTEFEKFHASIRIP--------- 266

  Fly   678 SCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLE 742
                                            |.........::||:||                
Human   267 --------------------------------PFDNDLDHPGERQQISS---------------- 283

  Fly   743 AKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTI 807
             .||||||:.|.:|.|||::.|||||:..|.:.| :...:|..||....||||.||.:||::||.
Human   284 -TRERKAARILGLILGAFILSWLPFFIKELIVGL-SIYTVSSEVADFLTWLGYVNSLINPLLYTS 346

  Fly   808 FSPEFRQAFKRIL 820
            |:.:|:.|||:::
Human   347 FNEDFKLAFKKLI 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 83/187 (44%)
TM helix 1 228..254 CDD:320454 8/25 (32%)
TM helix 2 261..287 CDD:320454 17/25 (68%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 8/21 (38%)
TM helix 5 383..412 CDD:320454 14/29 (48%)
7tm_GPCRs <743..816 CDD:475119 33/72 (46%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 12/24 (50%)
HTR1ENP_000856.1 7tmA_5-HT1E 23..355 CDD:320457 140/591 (24%)
TM helix 1 24..50 CDD:320457 8/26 (31%)
TM helix 2 57..83 CDD:320457 17/25 (68%)
TM helix 3 95..125 CDD:320457 19/29 (66%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 119..121 1/1 (100%)
TM helix 4 137..159 CDD:320457 8/21 (38%)
TM helix 5 179..208 CDD:320457 13/28 (46%)
TM helix 6 284..314 CDD:320457 17/29 (59%)
TM helix 7 323..348 CDD:320457 12/24 (50%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 340..344 2/3 (67%)

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