Protein Alignment 5-HT1A and HTR1D

DIOPT Version :9

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 160/633 - (25%)
• Similarity: 234/633 - (36%)
• Gaps: 282/633 - (44%)

  Fly   193 ANRSGQLDLINGTGGLNVTTSKVAEDDFT-QLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERN 256
            :|||           ||.|.:..|.|..| |.|:::: :|:|.::.|.|::.|.||:..|:|.|.
Human    16 SNRS-----------LNATETSEAWDPRTLQALKISL-AVVLSVITLATVLSNAFVLTTILLTRK 68

  Fly   257 LQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIA 321
            |...||||:.|||..||.|:.||||:...|.|:..|..|..|||||.|.|:.|||||||||..||
Human    69 LHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIA 133

  Fly   322 VDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMV-SQDV 384
            :|||||:|: ::|...||:.....||..||..::.:|:.|.| |:.....:  |...|:| :..:
Human   134 LDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQE--EMSDCLVNTSQI 195

  Fly   385 SYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRL 449
            ||.:::||..||:|.::::.||.:||:.||.||             .|.|.             |
Human   196 SYTIYSTCGAFYIPSVLLIILYGRIYRAARNRI-------------LNPPS-------------L 234

  Fly   450 RLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPST 514
            ...||:||...||||                 |:|..::|:
Human   235 YGKRFTTAHLITGSA-----------------GSSLCSLNS------------------------ 258

  Fly   515 SGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGP 579
                          :..:|.|.:..|...
Human   259 --------------SLHEGHSHSAGSPLF------------------------------------ 273

  Fly   580 QPTTATSAMTAAGTNESEDQCKANGVEV-LEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTI 643
                                  .|.|:: |.|..|:
Human   274 ----------------------FNHVKIKLADSALE----------------------------- 287

  Fly   644 TSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQ 708
                                                                             
Human   288 ----------------------------------------------------------------- 287

  Fly   709 QPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALT 773
                                         ::.:.|.|||||.|.|.||.|||::|||||||::|.
Human   288 -----------------------------RKRISAARERKATKILGIILGAFIICWLPFFVVSLV 323

  Fly   774 MPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            :|:|. :|.|..::...|.||||.||.:||:|||:|:.||||||::|:
Human   324 LPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	78/187 (42%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	22/29 (76%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:355774	42/73 (58%)
		TM helix 6	747..772	CDD:341315	17/24 (71%)
		TM helix 7	784..809	CDD:341315	12/24 (50%)
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/17 (29%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	148/597 (25%)
		TM helix 1	40..66	CDD:320455	8/26 (31%)
		TM helix 2	73..99	CDD:320455	14/25 (56%)
		TM helix 3	111..141	CDD:320455	22/29 (76%)
		Agonist binding. /evidence=ECO:0000250	114..123		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	7/23 (30%)
		TM helix 5	194..223	CDD:320455	11/28 (39%)
		TM helix 6	294..324	CDD:320455	20/29 (69%)
		Agonist binding. /evidence=ECO:0000250	314..318		3/3 (100%)
		TM helix 7	335..360	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	352..356		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920