Protein Alignment 5-HT1A and HTR1A

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000515.2
• Gene: HTR1A / 3350
• HGNCID: 5286
• Length: 422
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 176/620 - (28%)
• Similarity: 247/620 - (39%)
• Gaps: 230/620 - (37%)

  Fly   203 NGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 267
            |.||..:||.|           ...:||:|||.:|...::||..|:|||.|||:||||||||:.|
Human    24 NTTGISDVTVS-----------YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGS 77

  Fly   268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-I 331
            |||.||.|:.||:|:.|:|::...|.||...||::.:.||||||:|||||.|||:|||||:|: |
Human    78 LAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142

  Fly   332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFY 396
            ||::.||..|...:|...|....::|:.|..||:.|:  .|.:...|.:|:|..|.:::|...||
Human   143 DYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPE--DRSDPDACTISKDHGYTIYSTFGAFY 205

  Fly   397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKT 461
            :|||::|.||.:|::.||.|| |:..:.|:....:.:.....|...|              ||..
Human   206 IPLLLMLVLYGRIFRAARFRI-RKTVKKVEKTGADTRHGASPAPQPK--------------KSVN 255

  Fly   462 GSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLV 526
            |.        ||.|                            ..|.|||
Human   256 GE--------SGSR----------------------------NWRLGVE---------------- 268

  Fly   527 ALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAA 591
                    |.|..:...||..   ||.|||.
Human   269 --------SKAGGALCANGAV---RQGDDGA---------------------------------- 288

  Fly   592 GTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTS 656
                        .:||:|..::....|.:
Human   289 ------------ALEVIEVHRVGNSKEHL------------------------------------ 305

  Fly   657 QGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQ 721
                                       ||...|..:|..|....|:
Human   306 ---------------------------PLPSEAGPTPCAPASFERK------------------- 324

  Fly   722 QQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLC-AACQISDS 785
                   |......|||..|  .||||..|||.||.|.|::||||||::||.:|.| ::|.:...
Human   325 -------NERNAEAKRKMAL--ARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTL 380

  Fly   786 VASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            :.::..||||.||.||||||..|:.:|:.|||:|:
Human   381 LGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	88/186 (47%)
		TM helix 1	228..254	CDD:320454	12/25 (48%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	21/29 (72%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	12/28 (43%)
		7tm_GPCRs	<743..816	CDD:475119	36/73 (49%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	12/24 (50%)
HTR1A	NP_000515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		7tmA_5-HT1A_vertebrates	37..411	CDD:320453	166/590 (28%)
		TM helix 1	38..64	CDD:320453	12/25 (48%)
		TM helix 2	71..97	CDD:320453	15/25 (60%)
		TM helix 3	109..139	CDD:320453	21/29 (72%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	5/21 (24%)
		TM helix 5	192..221	CDD:320453	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..262		8/76 (11%)
		TM helix 6	338..368	CDD:320453	19/29 (66%)
		TM helix 7	379..404	CDD:320453	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		3/3 (100%)