DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Dop2R

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_001014758.2 Gene:Dop2R / 33007 FlyBaseID:FBgn0053517 Length:905 Species:Drosophila melanogaster


Alignment Length:1004 Identity:236/1004 - (23%)
Similarity:361/1004 - (35%) Gaps:381/1004 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 GSLALKPPPTDVNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRA--------LTTKQ 141
            |::|.:|..:...||....|:..|||| .||..||:::.|||..:..||..|        |..:.
  Fly    18 GTMAAQPLSSTAATTAAATGATAATAA-TAATTSATLSTAAASTSTTAAPSAGATWINHHLAVEA 81

  Fly   142 DATSSPASSPALQ-----------------------------LID-----------------MDN 160
            | :|.||:....|                             |||                 ...
  Fly    82 D-SSQPANGSDAQAGVEGPTMPAGYLPLYEDVETAAEDAGYALIDDISEWLLGSVGSEAAVGGPE 145

  Fly   161 NYTNVAV----GLGAML--LNDT------------------------------------------ 177
            |.||:||    |..|.|  ||.|                                          
  Fly   146 NSTNLAVTGANGTLAWLEALNSTQPAQSNSSAEDGERGRYSLRSFVEQQLAGGGAAGAGDGGDAG 210

  Fly   178 --LLLEGNDSSL---------------FG-------------EMLANR------------SGQLD 200
              |:..|.:::|               ||             |.|.||            ||.:.
  Fly   211 IALIDSGEEAALDNVADAETDYGMLGGFGDAELLQRTATVARETLGNRTAPSTTSYDGGGSGDVG 275

  Fly   201 L-----------INGTGGLNVTTSKVAEDDFTQ------------------------------LL 224
            :           :.|.||...:|..:..::|..                              ||
  Fly   276 VAGGLAGTAGGGVGGAGGSGGSTFMLLLENFNDYFPNYNGSTVSGTSTIAPGVAITGSRGSGLLL 340

  Fly   225 RMAVT---------------------------------SVLLGLMILVTIIGNVFVIAAIILERN 256
            ...:|                                 :::|.|..::|:.||:.||.::..||:
  Fly   341 EQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWALILILFPILTLFGNILVILSVCRERS 405

  Fly   257 LQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIA 321
            ||.|.||.:.|||:|||.||.:|||....:.::..|.|...:||.:.:.||:|.|:||.:||||:
  Fly   406 LQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAIS 470

  Fly   322 VDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGW-----KDPDYLQRIEQQKCMV 380
            :|||.|||. |.|...:.|.||.:.|..||..:..:......|.     ::||.        | .
  Fly   471 IDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDV--------C-A 526

  Fly   381 SQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRP--RPVDAAVNNNQPDGGAATDTK 443
            ..:..:.::::..:||:|.::::.|||.|::..|.|..::|.  :|     :.::..||:..: .
  Fly   527 FYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRAARKP-----HLSELTGGSVIE-N 585

  Fly   444 LHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTV---NTVEDTEFSSSNVDSKS 505
            :.:.| ||...:...|:..|.:             |.|..:|||.   |..||....|.::|.  
  Fly   586 IAQTR-RLAETALDSSRHASRI-------------LPDEAATNTASGSNEEEDENAISPDIDD-- 634

  Fly   506 RAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREEL 570
                             .|::.    ..|||....|.|                          :
  Fly   635 -----------------CHVIV----NDKSTEFMLATV--------------------------V 652

  Fly   571 EDQDEQVGPQPTTATSAMTA-AGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGG 634
            |:....|..|.||....:.| ...|.......:|..:||                     .|...
  Fly   653 EETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVL---------------------AGVAP 696

  Fly   635 ASTSNATTITSISALS-PQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP 698
            ||.|.||:....|:.| |.:|...|.          |.:.|:::|  |..|   |.::||...||
  Fly   697 ASASAATSAAPRSSGSPPDSPLPSGA----------TLQRSSVSS--QRRP---TGDDSPKRGEP 746

  Fly   699 RSR-----------QPTTPQQQPHQQAHQQQQQQQQLSSIAN---------------PMQKVN-- 735
            ..|           :|.:..:...|:|....:....||:.:.               .:.||:  
  Fly   747 ALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKA 811

  Fly   736 --KRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAA----CQISDSVASLFLWLG 794
              |::|...||:||||.|||||:.|.|:.||||||...:...:||.    |:...:...:..|||
  Fly   812 SKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLG 876

  Fly   795 YFNSTLNPVIYTIFSPEFRQAFKRILFGG 823
            |.||.:||||||||:||||:|||:|:..|
  Fly   877 YINSFVNPVIYTIFNPEFRKAFKKIMHMG 905

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 65/224 (29%)
TM helix 1 228..254 CDD:320454 8/58 (14%)
TM helix 2 261..287 CDD:320454 13/25 (52%)
TM helix 3 299..329 CDD:320454 16/29 (55%)
TM helix 4 340..362 CDD:320454 5/21 (24%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 40/76 (53%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 13/24 (54%)
Dop2RNP_001014758.2 7tmA_D2-like_dopamine_R 376..>565 CDD:320181 66/197 (34%)
TM helix 1 377..403 CDD:320181 7/25 (28%)
TM helix 2 410..436 CDD:320181 13/25 (52%)
TM helix 3 448..478 CDD:320181 16/29 (55%)
TM helix 4 490..513 CDD:320181 5/22 (23%)
TM helix 5 529..558 CDD:320181 7/28 (25%)
7tm_GPCRs <822..898 CDD:475119 39/75 (52%)
TM helix 6 828..850 CDD:320181 13/21 (62%)
TM helix 7 866..891 CDD:320181 13/24 (54%)

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