Protein Alignment 5-HT1A and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_061501849.1
• Gene: Octalpha2R / 3289716
• VectorBaseID: AGAMI1_006243
• Length: 636
• Species: Anopheles gambiae
• Alignment Length: 792
• Identity: 206/792 - (26%)
• Similarity: 325/792 - (41%)
• Gaps: 210/792 - (26%)

  Fly    82 DFIGSLALKPPPTD---------VNTTTTTAGSP-LATAALAAAAASASVAAAAARITAKAAHRA 136
            ||:.|     ||.:         |....|..|.| :...:||.|||:|:.|||||
Mosquito     2 DFVSS-----PPGNITQEDFLAIVGANGTVGGGPTMFNDSLAVAAAAAAAAAAAA---------- 51

  Fly   137 LTTKQDATSSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDL 201
                 ...:.|..:               |.|:|.
Mosquito    52 -----GGVAGPGGT---------------AAGVGP------------------------------ 66

  Fly   202 INGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVA 266
                 |.|:|....|......|..:.:.|:::.::::|.::||:.||.||..|:.|:|:.|:.:|
Mosquito    67 -----GENLTILHGAYPSGYTLPHIIIASIIVTILMIVIVVGNMLVIIAIATEKTLKNIQNWFIA 126

  Fly   267 SLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN- 330
            ||||||.|:..::||.....|:...||.|...||:.::.|||.||:||::|..|::||||::|.
Mosquito   127 SLAVADFFLGLVIMPFSLANELMGYWIFGNWWCDVHSAMDVLLCTSSIMNLCLISLDRYWSITKA 191

  Fly   331 IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTF 395
            |:|:.|||..|...||..||..:.:|.:.|..|||.......:|..:|.:|||:.|.:::...:|
Mosquito   192 IEYLKSRTPARAAFMIAAVWIMSALVCIPPLLGWKAQRPEGHVELPQCQLSQDIGYVLYSALGSF 256

  Fly   396 YVPLLVILALYWKIYQTARKRIHRR-RPRPV-----------------------DAAVNNNQPDG 436
            |:|..:::.:|.:||..|:.|..|. |.:|:                       .|:.|||| ..
Mosquito   257 YIPSCIMVFVYIRIYFAAKARARRGIRKKPLKPPSEQDTSFTRNAGTVPMPSLPSASSNNNQ-SA 320

  Fly   437 GAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNV 501
            .||...:.|.::|..|    |:....:.:....|...|..:.:          .|...:|:|...
Mosquito   321 AAAAHHQQHPVQLSSG----AQGGGSTQIATIEPPPRGTPMPI----------PVVTCDFASDMS 371

  Fly   502 DSKSRAGVEAPSTSGNQIATVSHL---------VALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQ 557
            .|      ||.:...:|...:|.:         |....|||:||       ||:..:|...:...
Mosquito   372 TS------EAATAEQDQHGPISPVALEPKDTLKVTQPAQQGRST-------NGITAAGAATEPVA 423

  Fly   558 RPEHGEQEDREELEDQDEQVGPQ--PTTATSAMTAAGTNESEDQCKANGVEVLE----DPQLQQQ 616
            .|.......|......|..:..:  |:::.|.:.:        :|..  |:.|:    .|...:.
Mosquito   424 SPSSAAARSRALSVGIDTDMVSEFDPSSSDSGVIS--------RCAV--VKPLKFRLCQPIFGKG 478

  Fly   617 LEQVQQLQKSVKSGGGGGASTSNATTITS--ISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSC 679
            ..:.:|........||..|...||...|.  ::|...|...||           :.|...|.::|
Mosquito   479 KAKARQANAKAAGHGGAHAGRGNAPNCTQPMLAAPGGQQAISQ-----------LIAAKQTDSAC 532

  Fly   680 NQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK 744
            ::..|..        .|:|:.|.|                               .|.|..:..|
Mosquito   533 SELEPAL--------PPKPKPRDP-------------------------------EKEKRRIARK 558

  Fly   745 RERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFS 809
            :|::|...|.:|.|:|:.||||||.:.:.:|:|..|.|.||..||..||||.||.|||.|||||:
Mosquito   559 KEKRATLILGLIMGSFIACWLPFFFLYILVPVCPDCHIPDSAFSLAFWLGYMNSALNPAIYTIFN 623

  Fly   810 PEFRQAFKRILF 821
            .:||:||:||||
Mosquito   624 KDFRRAFRRILF 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	69/186 (37%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	15/29 (52%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	8/28 (29%)
		7tm_GPCRs	<743..816	CDD:475119	37/72 (51%)
		TM helix 6	750..772	CDD:410628	10/21 (48%)
		TM helix 7	784..809	CDD:410628	17/24 (71%)
Octalpha2R	XP_061501849.1	None