Protein Alignment 5-HT1A and TAAR6

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_778237.1
• Gene: TAAR6 / 319100
• HGNCID: 20978
• Length: 345
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 110/662 - (16%)
• Similarity: 170/662 - (25%)
• Gaps: 353/662 - (53%)

  Fly   180 LEGNDSSLFGEML--ANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTII 242
            :..|.|.|....|  ||.:|....|..:.|..|                 :..::.|...::.:.
Human     1 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRV-----------------ILYIVFGFGAVLAVF 48

  Fly   243 GNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDV 307
            ||:.|:.:|:..:.|.:..|:||||||.||..|...|||...|..:...|..|...|...|.|||
Human    49 GNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDV 113

  Fly   308 LCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCV---WTAAVIVSLAPQFGWKDPDY 369
            ..|.:|:.||..|::|||.|||  |.:...|...|.:...|:   |...::.|.|..:.....|.
Human   114 AFCYSSLFHLCFISIDRYIAVT--DPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDG 176

  Fly   370 LQRIEQQ-------KCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDA 427
            |:.:...       :.:|:|:   .|.....:|::|..:::.||..|:..|     ||:.:.::
Human   177 LEELSDALNCIGGCQTVVNQN---WVLTDFLSFFIPTFIMIILYGNIFLVA-----RRQAKKIE- 232

  Fly   428 AVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVE 492
                                                                         ||..
Human   233 -------------------------------------------------------------NTGS 236

  Fly   493 DTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQ 557
            .||.||.:.  |:|.
Human   237 KTESSSESY--KARV-------------------------------------------------- 249

  Fly   558 RPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQ 622
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   623 LQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCG 687
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   688 TANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKT 752
                                                                   |:||||||||
Human   250 -------------------------------------------------------ARRERKAAKT 259

  Fly   753 LAIITGAFVVCWLPFFV-------MALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSP 810
            |.:...||::.|||:.:       |....|.|        :..:..|..|:||.:||:||.:|.|
Human   260 LGVTVVAFMISWLPYSIDSLIDAFMGFITPAC--------IYEICCWCAYYNSAMNPLIYALFYP 316

  Fly   811 EFRQAFKRILFG 822
            .||:|.|.|:.|
Human   317 WFRKAIKVIVTG 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	55/195 (28%)
		TM helix 1	228..254	CDD:320454	5/25 (20%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	14/29 (48%)
		TM helix 4	340..362	CDD:320454	5/24 (21%)
		TM helix 5	383..412	CDD:320454	6/28 (21%)
		7tm_GPCRs	<743..816	CDD:475119	30/79 (38%)
		TM helix 6	750..772	CDD:410628	10/28 (36%)
		TM helix 7	784..809	CDD:410628	8/24 (33%)
TAAR6	NP_778237.1	7tmA_TAAR6_8_9	33..322	CDD:320439	97/622 (16%)
		TM helix 1	34..60	CDD:320439	5/25 (20%)
		TM helix 2	67..93	CDD:320439	14/25 (56%)
		TM helix 3	105..135	CDD:320439	14/29 (48%)
		TM helix 4	147..170	CDD:320439	4/22 (18%)
		TM helix 5	194..223	CDD:320439	8/31 (26%)
		TM helix 6	251..281	CDD:320439	14/29 (48%)
		TM helix 7	290..315	CDD:320439	9/32 (28%)