DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Adra1d

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_077809.2 Gene:Adra1d / 29413 RGDID:62064 Length:562 Species:Rattus norvegicus


Alignment Length:680 Identity:153/680 - (22%)
Similarity:224/680 - (32%) Gaps:305/680 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 AVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTS 230
            |.|.||::  .|...|.|.||. ||..|..||:::.....|||.|:...|.            ..
  Rat    45 ATGGGAVV--GTGSGEDNQSST-GEPGAAASGEVNGSAAVGGLVVSAQGVG------------VG 94

  Fly   231 VLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILG 295
            |.|...||..:.||:.||.::...|:||.|.||.:.:||||||.::..|:|..|..|:...|..|
  Rat    95 VFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFG 159

  Fly   296 PELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCVWTAAVIVSLA 359
            ...||:|.:.||||||||||.|..|:||||..|. ::.|....|..:...::..:|..|::||:.
  Rat   160 RTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVG 224

  Fly   360 PQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRP 424
            |..|||:|   ...:::.|.::::|.|.:|::.|:||:|:.||:.:|.::|..||          
  Rat   225 PLLGWKEP---VPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVAR---------- 276

  Fly   425 VDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVN 489
                                          ||.:|                              
  Rat   277 ------------------------------STTRS------------------------------ 281

  Fly   490 TVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQED 554
                           ..||::......:::....|                              
  Rat   282 ---------------LEAGIKREPGKASEVVLRIH------------------------------ 301

  Fly   555 DGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQ 619
                                                         |:                  
  Rat   302 ---------------------------------------------CR------------------ 303

  Fly   620 VQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHP 684
                          ||:||                       |....|..::|..||.|      
  Rat   304 --------------GAATS-----------------------AKGYPGTQSSKGHTLRS------ 325

  Fly   685 LCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKA 749
                                                  .||            ...|:..||:||
  Rat   326 --------------------------------------SLS------------VRLLKFSREKKA 340

  Fly   750 AKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQ 814
            ||||||:.|.||:||.|||.:.....|....:.|:.|..:..|||||||.:||:||...|.||::
  Rat   341 AKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKR 405

  Fly   815 AFKRILFGGHRPVHYRSGKLXIVHAKRRRR 844
            ||.|:|               ....:||||
  Rat   406 AFLRLL---------------RCQCRRRRR 420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 69/186 (37%)
TM helix 1 228..254 CDD:320454 8/25 (32%)
TM helix 2 261..287 CDD:320454 11/25 (44%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 5/21 (24%)
TM helix 5 383..412 CDD:320454 11/28 (39%)
7tm_GPCRs <743..816 CDD:475119 35/72 (49%)
TM helix 6 750..772 CDD:410628 14/21 (67%)
TM helix 7 784..809 CDD:410628 12/24 (50%)
Adra1dNP_077809.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10..71 12/28 (43%)
7tm_GPCRs 91..407 CDD:475119 127/601 (21%)
TM helix 1 93..117 CDD:410628 8/23 (35%)
TM helix 2 126..148 CDD:410628 10/21 (48%)
TM helix 3 164..186 CDD:410628 14/21 (67%)
TM helix 4 209..225 CDD:410628 4/15 (27%)
TM helix 5 246..269 CDD:410628 9/22 (41%)
TM helix 6 341..363 CDD:410628 14/21 (67%)
TM helix 7 375..400 CDD:410628 12/24 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..481
Blue background indicates that the domain is not in the aligned region.

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