Protein Alignment 5-HT1A and Adra1a

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_058887.2
• Gene: Adra1a / 29412
• RGDID: 2055
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 622
• Identity: 126/622 - (20%)
• Similarity: 202/622 - (32%)
• Gaps: 291/622 - (46%)

  Fly   203 NGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 267
            |.:.|.|.|.....    ..:.:..:..|:||.:|:..::||:.||.::...|:|.:|.:|.:.:
  Rat     7 NASEGSNCTHPPAP----VNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVN 67

  Fly   268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NI 331
            ||||||.:...|:|..|::||...|..|...|:||.:.|||||||||:.|..|::|||..|: .:
  Rat    68 LAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPL 132

  Fly   332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFY 396
            .|....|..|....:.|||..::::|:.|.|||:.|   ...::..|.::::..|.:|:...:||
  Rat   133 RYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQP---APEDETICQINEEPGYVLFSALGSFY 194

  Fly   397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKT 461
            |||.:||.:|.::|..|     :|..|.:.:.:..::.|....| .::||
  Rat   195 VPLAIILVMYCRVYVVA-----KRESRGLKSGLKTDKSDSEQVT-LRIHR--------------- 238

  Fly   462 GSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLV 526
                                                                             
  Rat   239 ----------------------------------------------------------------- 238

  Fly   527 ALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAA 591
                                                                             
  Rat   239 ----------------------------------------------------------------- 238

  Fly   592 GTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTS 656
                                             |:|.:.|||.:|..|.|..:
  Rat   239 ---------------------------------KNVPAEGGGVSSAKNKTHFS------------ 258

  Fly   657 QGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQ 721
                                                                             
  Rat   259 ----------------------------------------------------------------- 258

  Fly   722 QQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA---ACQIS 783
                            ...|:..||:||||||.|:.|.||:||||||   |.||:.:   ..:.|
  Rat   259 ----------------VRLLKFSREKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSFFPDFKPS 304

  Fly   784 DSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ::|..:..||||.||.:||:||...|.||::||:.:|
  Rat   305 ETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/186 (36%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	10/25 (40%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	36/75 (48%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	119/592 (20%)
		TM helix 1	28..54	CDD:320448	8/25 (32%)
		TM helix 2	61..87	CDD:320448	10/25 (40%)
		TM helix 3	99..129	CDD:320448	17/29 (59%)
		TM helix 4	141..164	CDD:320448	6/22 (27%)
		TM helix 5	181..210	CDD:320448	11/28 (39%)
		TM helix 6	265..295	CDD:320448	21/32 (66%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		3/8 (38%)