Protein Alignment 5-HT1A and Drd3

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_058836.1
• Gene: Drd3 / 29238
• RGDID: 2521
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 161/609 - (26%)
• Similarity: 225/609 - (36%)
• Gaps: 227/609 - (37%)

  Fly   236 MILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG-WILGPELC 299
            :||..|.||..|.||::.||.||...||||.|||||||.||.||||.....|::.| |......|
  Rat    39 LILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICC 103

  Fly   300 DIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIH---SRTSNRVFMMIFCVWTAAVIVSLAP 360
            |::.:.||:.||||||:|.||::|||.||. .:.|.|   ..:..||.:||..||..|..||...
  Rat   104 DVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPL 168

  Fly   361 QFGWK---DPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIY----QTARKRIH 418
            .||:.   ||..        |.:| :..:.::::..:||||..|.:.:|.:||    |..||||.
  Rat   169 LFGFNTTGDPSI--------CSIS-NPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRIL 224

  Fly   419 RRRPRPVDAAVNNNQ--------PDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGR 475
            .|:         |:|        |...:.  .:||.:|    :||.                  |
  Rat   225 TRQ---------NSQCISIRPGFPQQSSC--LRLHPIR----QFSI------------------R 256

  Fly   476 ALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSS 540
            |..|.|  :|..:..:||.::.....|                 ..:|||
  Rat   257 ARFLSD--ATGQMEHIEDKQYPQKCQD-----------------PLLSHL--------------- 287

  Fly   541 AAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGV 605
                            |.|..|:                         |..|.......|:..
  Rat   288 ----------------QPPSPGQ-------------------------THGGLKRYYSICQDT-- 309

  Fly   606 EVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMT 670
             .|..|.|:                ||.|.|
  Rat   310 -ALRHPSLE----------------GGAGMS---------------------------------- 323

  Fly   671 AKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVN 735
                                     |..|:|...:|...|        :...::..::|.....:
  Rat   324 -------------------------PVERTRNSLSPTMAP--------KLSLEVRKLSNGRLSTS 355

  Fly   736 KRKETLEAK----RERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYF 796
            .|...|:.:    ||:||.:.:.|:.|||:|||||||:..:....|.||.:|..:.....||||.
  Rat   356 LRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV 420

  Fly   797 NSTLNPVIYTIFSPEFRQAFKRIL 820
            ||.|||||||.|:.|||:||.:||
  Rat   421 NSALNPVIYTTFNVEFRKAFLKIL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	76/188 (40%)
		TM helix 1	228..254	CDD:320454	8/17 (47%)
		TM helix 2	261..287	CDD:320454	17/25 (68%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	9/21 (43%)
		TM helix 5	383..412	CDD:320454	8/32 (25%)
		7tm_GPCRs	<743..816	CDD:475119	36/76 (47%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
Drd3	NP_058836.1	7tmA_D3_dopamine_R	30..440	CDD:320436	157/603 (26%)
		TM helix 1	31..57	CDD:320436	8/17 (47%)
		TM helix 2	64..87	CDD:320436	17/22 (77%)
		TM helix 3	103..133	CDD:320436	17/29 (59%)
		TM helix 4	150..168	CDD:320436	8/17 (47%)
		TM helix 5	185..210	CDD:320436	6/24 (25%)
		TM helix 6	368..398	CDD:320436	15/29 (52%)
		TM helix 7	408..433	CDD:320436	13/24 (54%)