Protein Alignment 5-HT1A and drd2a

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_898891.1
• Gene: drd2a / 282557
• ZFINID: ZDB-GENE-021119-2
• Length: 448
• Species: Danio rerio
• Alignment Length: 600
• Identity: 158/600 - (26%)
• Similarity: 241/600 - (40%)
• Gaps: 198/600 - (33%)

  Fly   230 SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWIL 294
            ::||.|:|.|.:.|||.|..|:..|:.||...|||:.|||||||.||.||||.....|:...|..
Zfish    36 AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRF 100

  Fly   295 GPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSN--RVFMMIFCVWTAAVIVS 357
            ....|||:.:.||:.||||||:|.||::|||.||......::|.|:  ||.:||..||..:..:|
Zfish   101 STIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWILSFAIS 165

  Fly   358 LAPQFGWKD----PDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIY---QTARK 415
            ....||..:    .|.|       |::: :.::.|:::..:||||.::.|.:|.:||   :..||
Zfish   166 CPLLFGLNNTVTHDDAL-------CVIA-NPAFVVYSSIVSFYVPFIITLLVYVQIYVVLRKRRK 222

  Fly   416 RIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLV 480
            |::.:|..||              ||..:.         ||.|..|..
Zfish   223 RVNTKRTCPV--------------TDMDMS---------STIKKCTHP----------------- 247

  Fly   481 DGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNG 545
                       :|.:..:..|.|           |||           .....|:.......||
Zfish   248 -----------DDVKLCTVIVKS-----------SGN-----------CPVNNKNVIFIKEVVN- 278

  Fly   546 MAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLED 610
                           :|:....:|:                      ||              .:
Zfish   279 ---------------NGDDIQMDEI----------------------TN--------------RN 292

  Fly   611 PQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTST 675
            |..|::.:|         |||    |..|:..:.|....:..:|.|...|:.....|    .||:
Zfish   293 PSRQRKQDQ---------SGG----SQQNSRLVNSNLRETDISPPSPEAGVKPERNG----NTSS 340

  Fly   676 LTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKET 740
            :|...::..:              ...||...|                    ..::.:||||
Zfish   341 ITKGAKAFEI--------------QVSPTGKTQ--------------------TSVKTLNKRK-- 369

  Fly   741 LEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIY 805
            :..::|:||.:.|||:.|.|::||||||:   |..:...||:...:.:.|.||||.||.:||:||
Zfish   370 ISQQKEKKATQMLAIVLGVFIICWLPFFI---THIVNTYCQVPPELYTAFTWLGYVNSAVNPIIY 431

  Fly   806 TIFSPEFRQAFKRIL 820
            |.|:.|||:||.:||
Zfish   432 TTFNIEFRKAFIKIL 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	73/191 (38%)
		TM helix 1	228..254	CDD:320454	10/23 (43%)
		TM helix 2	261..287	CDD:320454	16/25 (64%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	7/23 (30%)
		TM helix 5	383..412	CDD:320454	9/31 (29%)
		7tm_GPCRs	<743..816	CDD:475119	33/72 (46%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	12/24 (50%)
drd2a	NP_898891.1	7tmA_D2-like_dopamine_R	33..442	CDD:320181	154/594 (26%)
		TM helix 1	34..60	CDD:320181	10/23 (43%)
		TM helix 2	67..93	CDD:320181	16/25 (64%)
		TM helix 3	105..135	CDD:320181	18/29 (62%)
		TM helix 4	148..171	CDD:320181	7/22 (32%)
		TM helix 5	187..216	CDD:320181	9/28 (32%)
		TM helix 6	218..403	CDD:320181	63/365 (17%)
		TM helix 7	410..435	CDD:320181	12/24 (50%)