DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and drd3

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:XP_005162730.1 Gene:drd3 / 282554 ZFINID:ZDB-GENE-021119-1 Length:472 Species:Danio rerio


Alignment Length:665 Identity:175/665 - (26%)
Similarity:245/665 - (36%) Gaps:224/665 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 LNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMIL 238
            ||.:..|....||  ||.|.|.|..    :.|.|.|.:.:...|:     .:....::|..|:||
Zfish    12 LNRSSTLMAMFSS--GEWLWNDSEH----SFTPGGNYSPASGVEE-----AKRNYYAMLYSLLIL 65

  Fly   239 VTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG-WILGPELCDIW 302
            ..:.|||.|..|::.||.||...||||.|||||||.||.||||.....|:..| |:.....|:::
Zfish    66 AIVFGNVLVCIAVLRERALQTTTNYLVVSLAVADLLVASLVMPWAVYLEVVGGAWLFSRLYCNVF 130

  Fly   303 TSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSN---RVFMMIFCVWTAAVIVSLAPQFGW 364
            .:.||:.||||||:|.||::|||.||. :..:::.|.:   ||.:||..||..|..||....||:
Zfish   131 VTLDVMMCTASILNLCAISIDRYTAVV-MPVLYNTTHSSRKRVSVMIATVWVLAFAVSCPLLFGF 194

  Fly   365 KDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAV 429
            ...|     :...|.:| :..:.::::..:||:|..|.|.:|.:||...|    |||.:      
Zfish   195 NTTD-----DPAVCSIS-NPDFVIYSSVVSFYLPFAVTLLVYVRIYIFLR----RRRKK------ 243

  Fly   430 NNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDT 494
                                     .|.:..:|.....|.|.|....|      ..:......|.
Zfish   244 -------------------------ITFRQGSGKVQPASAPPSVEMCL------QDDAHKEKRDL 277

  Fly   495 EFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPS---------- 549
            .....||.::|:..|..|....|.:.             :...:::.|.|.:.|.          
Zfish   278 SPIRINVITESKEQVIRPRLLANCLR-------------RKRPQTAPAENSLLPPVITLNYCSIS 329

  Fly   550 ----GRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLED 610
                .|.|.|.         :|||.|..||                                   
Zfish   330 QASFARTEQDA---------NREEEEGGDE----------------------------------- 350

  Fly   611 PQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTST 675
                   |||......||       ..:|..|.||:     :.|.:     |.|...|..|:   
Zfish   351 -------EQVAVRSCEVK-------KLANGRTHTSL-----RPPRA-----AHAMVCPSQAR--- 388

  Fly   676 LTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKET 740
               |...|                                                         
Zfish   389 ---CRSMH--------------------------------------------------------- 393

  Fly   741 LEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIY 805
               .:|:||.:.|||:.|.|::|||||||..:....|.||.|...|.|.|.||||.||.||||||
Zfish   394 ---SKEKKATQMLAIVLGVFLICWLPFFVTHILNTHCRACHIPPEVYSAFTWLGYVNSALNPVIY 455

  Fly   806 TIFSPEFRQAFKRIL 820
            |.|:.|||:||.:||
Zfish   456 TTFNIEFRRAFIKIL 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 73/189 (39%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 17/25 (68%)
TM helix 3 299..329 CDD:320454 16/29 (55%)
TM helix 4 340..362 CDD:320454 9/24 (38%)
TM helix 5 383..412 CDD:320454 8/28 (29%)
7tm_GPCRs <743..816 CDD:475119 39/72 (54%)
TM helix 6 750..772 CDD:410628 12/21 (57%)
TM helix 7 784..809 CDD:410628 16/24 (67%)
drd3XP_005162730.1 7tmA_D3_dopamine_R 54..466 CDD:320436 157/606 (26%)
TM helix 1 55..81 CDD:320436 9/25 (36%)
TM helix 2 88..111 CDD:320436 17/22 (77%)
TM helix 3 127..157 CDD:320436 16/29 (55%)
TM helix 4 172..190 CDD:320436 8/17 (47%)
TM helix 5 207..232 CDD:320436 6/24 (25%)
TM helix 6 394..424 CDD:320436 15/29 (52%)
TM helix 7 434..459 CDD:320436 16/24 (67%)

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