DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and adra2da

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_919345.2 Gene:adra2da / 266754 ZFINID:ZDB-GENE-021010-4 Length:408 Species:Danio rerio


Alignment Length:598 Identity:142/598 - (23%)
Similarity:222/598 - (37%) Gaps:231/598 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 AVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG 291
            |:..:::.|:||:||:|||.||.|::..|.|:...|..:.|||.||:.||.||:|.....||...
Zfish    31 AIIILVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLANEIMGY 95

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVI 355
            |..|...|..:.:.|||.||:||:||.||::||||:||. :.|...||..|:..||..||..:.:
Zfish    96 WYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRIKCMIAVVWLISAV 160

  Fly   356 VSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRR 420
            :|..|..       :.:.::::|:::.:..|.:.:...:|:.|.|:::.:|.|||:.|::|    
Zfish   161 ISFPPLI-------MTKHDEKECLINDETWYILSSCAVSFFAPGLIMITVYCKIYRVAKQR---- 214

  Fly   421 RPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNST 485
                                                                             
Zfish   215 ----------------------------------------------------------------- 214

  Fly   486 NTVNTVEDTEFSSSNVDSKSRAGVE-APSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPS 549
                  ..|.|.:.|       |:| .||.|.....          ::.|...:|        ||
Zfish   215 ------SSTVFVAKN-------GLERQPSQSETCFV----------RKDKFEKES--------PS 248

  Fly   550 GRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQ 614
            ....:..||        :|||:|.|.:     .:|.|...|.|:..|    |...||        
Zfish   249 SNSSESAQR--------QEELDDIDLE-----ESAASDSRARGSRFS----KRRRVE-------- 288

  Fly   615 QQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSC 679
                                                            ....||.       .||
Zfish   289 ------------------------------------------------GERRGPQ-------RSC 298

  Fly   680 NQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQ-QQQQQLSSIANPMQKVNKRKETLEA 743
            ..|                             ..|||:. .:||||:|           |..:..
Zfish   299 RVS-----------------------------WAAHQEPGSRQQQLAS-----------KSKVAQ 323

  Fly   744 KRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTI 807
            .||::....||::.|.||:||.|||.......:|. .|...:::..||.|:||.||::||:||||
Zfish   324 MREKRFTFVLAVVMGVFVLCWFPFFFTYSLQAVCGERCGPPEALFKLFFWIGYCNSSVNPIIYTI 388

  Fly   808 FSPEFRQAFKRIL 820
            |:.:||:|||:::
Zfish   389 FNRDFRKAFKKVV 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 66/186 (35%)
TM helix 1 228..254 CDD:320454 11/25 (44%)
TM helix 2 261..287 CDD:320454 11/25 (44%)
TM helix 3 299..329 CDD:320454 16/29 (55%)
TM helix 4 340..362 CDD:320454 7/21 (33%)
TM helix 5 383..412 CDD:320454 8/28 (29%)
7tm_GPCRs <743..816 CDD:475119 30/73 (41%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 13/24 (54%)
adra2daNP_919345.2 7tmA_alpha-2D_AR 44..397 CDD:320447 135/579 (23%)
TM helix 2 65..91 CDD:320447 11/25 (44%)
TM helix 3 103..133 CDD:320447 16/29 (55%)
TM helix 4 145..168 CDD:320447 7/29 (24%)
TM helix 5 181..210 CDD:320447 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..306 24/180 (13%)
TM helix 6 324..354 CDD:320447 12/29 (41%)
TM helix 7 365..390 CDD:320447 13/24 (54%)

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