DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and adra2c

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_997522.1 Gene:adra2c / 266752 ZFINID:ZDB-GENE-021010-3 Length:432 Species:Danio rerio


Alignment Length:599 Identity:144/599 - (24%)
Similarity:222/599 - (37%) Gaps:225/599 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 LLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGP 296
            |:..:||.||:|||.|:.|::..|.|:...|..:.|||.||:.||.|::|.....|:...|..|.
Zfish    41 LVSFLILFTIVGNVLVVIAVLTSRALKPPQNLFLVSLASADILVATLIIPFSLANELMGYWFFGE 105

  Fly   297 ELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAP 360
            ..|:|:.:.|||.||:||:||.||::||||:||. ::|...||..||..||..||..:.::|..|
Zfish   106 VWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKGMIVVVWLISAVISFPP 170

  Fly   361 QFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPV 425
            ..........:|  :..|.::....|.::::..:|:.|.::::.:|.:|||.|:.|......:..
Zfish   171 LISMDRNTVDER--RPMCQLNDHTWYILYSSIGSFFAPCVIMILVYIRIYQVAKTRTRNMSEKRR 233

  Fly   426 DAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSK--TGSAVGVSGPASGGRALGLVDGNSTNTV 488
            |       ||||:.|.    ||...|.|..:.:..  ..|:.|...||..               
Zfish   234 D-------PDGGSGTP----RLENGLSREDSRRENGHCSSSPGERKPAED--------------- 272

  Fly   489 NTVEDTEFSSSNVDSKSRAGVE-APSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQ 552
            |...|.|.|||:.:...|:..| |||                |:..:|:.|:|::          
Zfish   273 NPDADLEDSSSSDEKAKRSQNETAPS----------------KKDRRSSRKNSSS---------- 311

  Fly   553 EDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQL 617
                  .:|..::.|                                                  
Zfish   312 ------SKHSSRKSR-------------------------------------------------- 320

  Fly   618 EQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQS 682
                                                               .::|:..|.|    
Zfish   321 ---------------------------------------------------ASSKSLDLFS---- 330

  Fly   683 HPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK--- 744
                             ||:                                 ||:.|:..|   
Zfish   331 -----------------SRR---------------------------------KRRNTISRKKIS 345

  Fly   745 --RERKAAKTLAIITGAFVVCWLPFFVMALTMPLC-AACQISDSVASLFLWLGYFNSTLNPVIYT 806
              ||::....||::.|.|||||.|||.......:| ..|.|.|.:...|.|:||.||:|||||||
Zfish   346 QAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREPCAIPDPLFKFFFWIGYCNSSLNPVIYT 410

  Fly   807 IFSPEFRQAFKRIL 820
            ||:.:||:||::||
Zfish   411 IFNQDFRRAFQKIL 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 64/181 (35%)
TM helix 1 228..254 CDD:320454 10/21 (48%)
TM helix 2 261..287 CDD:320454 10/25 (40%)
TM helix 3 299..329 CDD:320454 17/29 (59%)
TM helix 4 340..362 CDD:320454 8/21 (38%)
TM helix 5 383..412 CDD:320454 6/28 (21%)
7tm_GPCRs <743..816 CDD:475119 35/78 (45%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 15/24 (63%)
adra2cNP_997522.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
7tmA_alpha2C_AR 36..420 CDD:320446 140/593 (24%)
TM helix 1 37..63 CDD:320446 10/21 (48%)
TM helix 2 70..96 CDD:320446 10/25 (40%)
TM helix 3 108..138 CDD:320446 17/29 (59%)
TM helix 4 150..173 CDD:320446 8/22 (36%)
TM helix 5 191..220 CDD:320446 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 224..342 40/330 (12%)
TM helix 6 347..377 CDD:320446 13/29 (45%)
TM helix 7 388..413 CDD:320446 15/24 (63%)
Blue background indicates that the domain is not in the aligned region.

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