DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Htr5a

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_037280.1 Gene:Htr5a / 25689 RGDID:2851 Length:357 Species:Rattus norvegicus


Alignment Length:630 Identity:148/630 - (23%)
Similarity:213/630 - (33%) Gaps:306/630 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 NRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQ 258
            |||  ||    |..|..:.|      |....|:.|.: |||.:...|...|:.|:|.|:..|...
  Rat    21 NRS--LD----TEALRTSQS------FLSAFRVLVLT-LLGFLAAATFTWNLLVLATILRVRTFH 72

  Fly   259 NVANYLVASLAVADLFVACLVMPLGAVYEIS-QGWILGPELCDIWTSCDVLCCTASILHLVAIAV 322
            .|.:.||||:|::|:.||.|||||..|:|:| :.|.||..||.:|.:||||||||||.::.|||:
  Rat    73 RVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137

  Fly   323 DRYWAVT-NIDY---IHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRIEQQKCMVSQ 382
            ||||::| :::|   ...|.||   :||...|..:.::|||| .|||.: .|.:..|:  |.||:
  Rat   138 DRYWSITRHLEYTLRARKRVSN---VMILLTWALSAVISLAPLLFGWGE-TYSELSEE--CQVSR 196

  Fly   383 DVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRL 447
            :.||.||:|...||:||.|:|.:|||||:.|:.|:..|:                          
  Rat   197 EPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRK-------------------------- 235

  Fly   448 RLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAP 512
                                                 ||:|:.:                     
  Rat   236 -------------------------------------TNSVSPI--------------------- 242

  Fly   513 STSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQV 577
                                                          ||..|.:|..         
  Rat   243 ----------------------------------------------PEAVEVKDAS--------- 252

  Fly   578 GPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATT 642
                                           :.||:                             
  Rat   253 -------------------------------QHPQM----------------------------- 257

  Fly   643 ITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQ 707
                                     ..|.:.:|:|...:.                         
  Rat   258 -------------------------VFTVRHATVTFQTEG------------------------- 272

  Fly   708 QQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMAL 772
                                           :|...::|::||..:.|:.|.||:||.||||..|
  Rat   273 -------------------------------DTWREQKEQRAALMVGILIGVFVLCWFPFFVTEL 306

  Fly   773 TMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFK 817
            ..||| :..|.....|:||||||.||..||:|||.|:..:..|||
  Rat   307 ISPLC-SWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFK 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 86/191 (45%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 14/25 (56%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 8/22 (36%)
TM helix 5 383..412 CDD:320454 16/28 (57%)
7tm_GPCRs <743..816 CDD:475119 33/72 (46%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 14/24 (58%)
Htr5aNP_037280.1 7tm_GPCRs 41..349 CDD:475119 135/595 (23%)
TM helix 1 43..67 CDD:320451 9/24 (38%)
TM helix 2 76..98 CDD:320451 13/21 (62%)
TM helix 3 115..137 CDD:320451 13/21 (62%)
TM helix 4 160..176 CDD:320451 5/15 (33%)
TM helix 5 198..221 CDD:320451 11/22 (50%)
TM helix 6 284..306 CDD:320451 11/21 (52%)
TM helix 7 317..342 CDD:320451 14/24 (58%)

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