DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT1A and Htr5a

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_037280.1 Gene:Htr5a / 25689 RGDID:2851 Length:357 Species:Rattus norvegicus


Alignment Length:630 Identity:148/630 - (23%)
Similarity:213/630 - (33%) Gaps:306/630 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 NRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQ 258
            |||  ||    |..|..:.|      |....|:.|.: |||.:...|...|:.|:|.|:..|...
  Rat    21 NRS--LD----TEALRTSQS------FLSAFRVLVLT-LLGFLAAATFTWNLLVLATILRVRTFH 72

  Fly   259 NVANYLVASLAVADLFVACLVMPLGAVYEIS-QGWILGPELCDIWTSCDVLCCTASILHLVAIAV 322
            .|.:.||||:|::|:.||.|||||..|:|:| :.|.||..||.:|.:||||||||||.::.|||:
  Rat    73 RVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137

  Fly   323 DRYWAVT-NIDY---IHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRIEQQKCMVSQ 382
            ||||::| :::|   ...|.||   :||...|..:.::|||| .|||.: .|.:..|:  |.||:
  Rat   138 DRYWSITRHLEYTLRARKRVSN---VMILLTWALSAVISLAPLLFGWGE-TYSELSEE--CQVSR 196

  Fly   383 DVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRL 447
            :.||.||:|...||:||.|:|.:|||||:.|:.|:..|:                          
  Rat   197 EPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRK-------------------------- 235

  Fly   448 RLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAP 512
                                                 ||:|:.:                     
  Rat   236 -------------------------------------TNSVSPI--------------------- 242

  Fly   513 STSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQV 577
                                                          ||..|.:|..         
  Rat   243 ----------------------------------------------PEAVEVKDAS--------- 252

  Fly   578 GPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATT 642
                                           :.||:                             
  Rat   253 -------------------------------QHPQM----------------------------- 257

  Fly   643 ITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQ 707
                                     ..|.:.:|:|...:.                         
  Rat   258 -------------------------VFTVRHATVTFQTEG------------------------- 272

  Fly   708 QQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMAL 772
                                           :|...::|::||..:.|:.|.||:||.||||..|
  Rat   273 -------------------------------DTWREQKEQRAALMVGILIGVFVLCWFPFFVTEL 306

  Fly   773 TMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFK 817
            ..||| :..|.....|:||||||.||..||:|||.|:..:..|||
  Rat   307 ISPLC-SWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFK 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 86/191 (45%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 14/25 (56%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 8/22 (36%)
TM helix 5 383..412 CDD:320454 16/28 (57%)
7tm_GPCRs <743..816 CDD:355774 33/72 (46%)
TM helix 6 747..772 CDD:341315 12/24 (50%)
TM helix 7 784..809 CDD:341315 14/24 (58%)
Htr5aNP_037280.1 7tm_GPCRs 41..349 CDD:421689 135/595 (23%)
TM helix 1 42..68 CDD:410628 9/26 (35%)
TM helix 2 75..101 CDD:410628 14/25 (56%)
TM helix 3 114..144 CDD:410628 19/29 (66%)
TM helix 4 156..177 CDD:410628 9/23 (39%)
TM helix 5 197..226 CDD:410628 16/28 (57%)
TM helix 6 278..308 CDD:410628 14/29 (48%)
TM helix 7 317..342 CDD:410628 14/24 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

Return to query results.
Submit another query.