Protein Alignment 5-HT1A and Drd4

DIOPT Version :9

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_006230583.1
• Gene: Drd4 / 25432
• RGDID: 2522
• Length: 389
• Species: Rattus norvegicus
• Alignment Length: 650
• Identity: 159/650 - (24%)
• Similarity: 219/650 - (33%)
• Gaps: 277/650 - (42%)

  Fly   182 GNDSSL-FGEMLANRSGQ-LDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLG--LMILVTII 242
            ||.|:. .|.:||.|..: |....|.||..                 |..:.|:|  |:|.:.:.
  Rat     2 GNSSATGDGGLLAGRGPESLGTGTGLGGAG-----------------AGAAALVGGVLLIGMVLA 49

  Fly   243 GNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG-WILGPELCDIWTSCD 306
            ||..|..::..||.||...||.:.|||.|||.:|.||:||....|:..| |:|.|.|||...:.|
  Rat    50 GNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMD 114

  Fly   307 VLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVW-----TAAVIVSLAPQFGWKD 366
            |:.|||||.:|.||:|||:.||| :...:::......::|...|     .||.:|........:|
  Rat   115 VMLCTASIFNLCAISVDRFVAVT-VPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRD 178

  Fly   367 PDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNN 431
            |...       |:  :|..|.|:::.|:|::|..::|.|||..::..|:
  Rat   179 PTVC-------CL--EDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRR---------------- 218

  Fly   432 NQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEF 496
                ..||..||||.        ...:..:|....||.|..|                    ..|
  Rat   219 ----WEAARHTKLHS--------RAPRRPSGPGPPVSDPTQG--------------------PLF 251

  Fly   497 SSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEH 561
            |.          ...||.|.....|||                                 .|||
  Rat   252 SD----------CPPPSPSLRTSPTVS---------------------------------SRPE- 272

  Fly   562 GEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKS 626
                                                                             
  Rat   273 ----------------------------------------------------------------- 272

  Fly   627 VKSGGGGGASTSNATTITSISALSPQTPTSQGVGIA-AAAAGPMTAKTSTLTSCNQSHPLCGTAN 690
                                |.|| |:|.|.|..:. ||.|.|
  Rat   273 --------------------SDLS-QSPCSPGCLLPDAALAQP---------------------- 294

  Fly   691 ESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAI 755
                 |.|.||:                                 ||...:.. |||||.:.|.:
  Rat   295 -----PAPSSRR---------------------------------KRGAKITG-RERKAMRVLPV 320

  Fly   756 ITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            :.|||::||.||||:.:|..||.||.:|..:.|...||||.||.|||:|||||:.|||..|::.|
  Rat   321 VVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/193 (35%)
		TM helix 1	228..254	CDD:320454	7/27 (26%)
		TM helix 2	261..287	CDD:320454	13/25 (52%)
		TM helix 3	299..329	CDD:320454	16/29 (55%)
		TM helix 4	340..362	CDD:320454	5/26 (19%)
		TM helix 5	383..412	CDD:320454	10/28 (36%)
		7tm_GPCRs	<743..816	CDD:355774	39/72 (54%)
		TM helix 6	747..772	CDD:341315	13/24 (54%)
		TM helix 7	784..809	CDD:341315	14/24 (58%)
Drd4	XP_006230583.1	7tm_1	50..370	CDD:278431	133/568 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910