Protein Alignment 5-HT1A and Htr1d

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_036984.1
• Gene: Htr1d / 25323
• RGDID: 2847
• Length: 374
• Species: Rattus norvegicus
• Alignment Length: 653
• Identity: 164/653 - (25%)
• Similarity: 240/653 - (36%)
• Gaps: 292/653 - (44%)

  Fly   184 DSSLFG--EMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVF 246
            :.||.|  :..:|||     :|.||..        :.:..|.||:::. |:|.::.|.|::.|.|
  Rat     5 NQSLEGLPQEASNRS-----LNATGAW--------DPEVLQALRISLV-VVLSIITLATVLSNAF 55

  Fly   247 VIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCT 311
            |:..|:|.:.|...||||:.|||..||.|:.||||:...|..::.|..|..|||||.|.|:.|||
  Rat    56 VLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120

  Fly   312 ASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQ 375
            ||||||..||:|||||:|: ::|...||:.....||..||..::.:|:.|.| |:.....:  |.
  Rat   121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLF-WRQATAHE--EM 182

  Fly   376 QKCMV-SQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAA 439
            ..|:| :..:||.:::||..||:|.::::.||.:||..||.||             .|.|.
  Rat   183 SDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRI-------------LNPPS---- 230

  Fly   440 TDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSK 504
                     |...||:||:..||||                 |:|..::|
  Rat   231 ---------LYGKRFTTAQLITGSA-----------------GSSLCSLN--------------- 254

  Fly   505 SRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREE 569
                   ||...:...||...:..
  Rat   255 -------PSLHESHTHTVGSPLFF----------------------------------------- 271

  Fly   570 LEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEV-LEDPQLQQQLEQVQQLQKSVKSGGGG 633
                                             |.|:: |.|..|:
  Rat   272 ---------------------------------NQVKIKLADSILE------------------- 284

  Fly   634 GASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP 698
                                                                             
  Rat   285 ----------------------------------------------------------------- 284

  Fly   699 RSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVC 763
                                                   ::.:.|.|||||.|||.||.|||::|
  Rat   285 ---------------------------------------RKRISAARERKATKTLGIILGAFIIC 310

  Fly   764 WLPFFVMALTMPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPV 827
            ||||||::|.:|:|. :|.|..::...|.||||.||.:||||||:|:.:|||||:|:       |
  Rat   311 WLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRV-------V 368

  Fly   828 HYR 830
            |:|
  Rat   369 HFR 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	76/187 (41%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	22/29 (76%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	43/73 (59%)
		TM helix 6	750..772	CDD:410628	15/21 (71%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
Htr1d	NP_036984.1	7tmA_5-HT1B_1D	32..364	CDD:320455	149/597 (25%)
		TM helix 1	37..63	CDD:320455	8/26 (31%)
		TM helix 2	70..96	CDD:320455	14/25 (56%)
		TM helix 3	108..138	CDD:320455	22/29 (76%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	150..173	CDD:320455	7/23 (30%)
		TM helix 5	191..220	CDD:320455	11/28 (39%)
		TM helix 6	291..321	CDD:320455	21/29 (72%)
		TM helix 7	332..357	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		3/3 (100%)