DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Drd5

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_036900.2 Gene:Drd5 / 25195 RGDID:2523 Length:475 Species:Rattus norvegicus


Alignment Length:630 Identity:128/630 - (20%)
Similarity:198/630 - (31%) Gaps:330/630 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 VTSVLLGLMILVTIIGNVFVIAAIILERNLQ-NVANYLVASLAVADLFVACLVMPLGAVYEISQG 291
            ||:.||.|:|:.|::|||.|.|||:..|:|: .:.|..:.||||:|||||.||||..||.|::..
  Rat    40 VTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGY 104

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVI 355
            |..| ..||||.:.|::|.|||||:|..|:||||||::. ..|....|.....:|:...||.:::
  Rat   105 WPFG-TFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSIL 168

  Fly   356 VSLAP-QFGW-KDPDYLQRIE------------------QQKCMVSQDVSYQVFATCCTFYVPLL 400
            :|..| |..| :|....|..|                  .:.|..|.:.:|.:.::..:||:|:.
  Rat   169 ISFIPVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRTYAISSSLISFYIPVA 233

  Fly   401 VILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAV 465
            :::..|.:||:.|:.:|.|                                              
  Rat   234 IMIVTYTRIYRIAQVQIRR---------------------------------------------- 252

  Fly   466 GVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAK 530
                                               :.|..||.                      
  Rat   253 -----------------------------------ISSLERAA---------------------- 260

  Fly   531 QQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNE 595
                                         ||.:                                
  Rat   261 -----------------------------EHAQ-------------------------------- 264

  Fly   596 SEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVG 660
               .|::.|                                                        
  Rat   265 ---SCRSRG-------------------------------------------------------- 270

  Fly   661 IAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLS 725
                                        |.|    |:|..|                       :
  Rat   271 ----------------------------AYE----PDPSLR-----------------------A 280

  Fly   726 SIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAA----------- 779
            ||                |:|.|..|||::|.|.||.||||||::...:|.|::           
  Rat   281 SI----------------KKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFP 329

  Fly   780 CQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGH 824
            | :|::...:|:|.|:.||:|||:||. |:.:||:.|.::|...|
  Rat   330 C-VSETTFDIFVWFGWANSSLNPIIYA-FNADFRKVFAQLLGCSH 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 75/206 (36%)
TM helix 1 228..254 CDD:320454 14/25 (56%)
TM helix 2 261..287 CDD:320454 16/25 (64%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 5/22 (23%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 33/83 (40%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 10/24 (42%)
Drd5NP_036900.2 7tm_GPCRs 39..364 CDD:475119 125/620 (20%)
TM helix 1 41..65 CDD:410628 13/23 (57%)
TM helix 2 75..97 CDD:410628 14/21 (67%)
TM helix 3 112..134 CDD:410628 12/21 (57%)
TM helix 4 157..173 CDD:410628 4/15 (27%)
TM helix 5 217..240 CDD:410628 4/22 (18%)
TM helix 6 289..311 CDD:410628 13/21 (62%)
TM helix 7 333..358 CDD:410628 11/25 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..443
Blue background indicates that the domain is not in the aligned region.

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