DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Adra1b

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_058687.2 Gene:Adra1b / 24173 RGDID:2054 Length:515 Species:Rattus norvegicus


Alignment Length:655 Identity:148/655 - (22%)
Similarity:222/655 - (33%) Gaps:302/655 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   197 GQLDLINGTGGLNVTTSK--VAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQN 259
            |:|...|.||. |.|:|.  :.:.|.|:.:.:   .::||..||..|:||:.||.::...|:|:.
  Rat    18 GELKDDNFTGP-NQTSSNSTLPQLDVTRAISV---GLVLGAFILFAIVGNILVILSVACNRHLRT 78

  Fly   260 VANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDR 324
            ..||.:.:||:|||.::..|:|..|..|:...|:||...||||.:.||||||||||.|.||::||
  Rat    79 PTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143

  Fly   325 YWAVT-NIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQV 388
            |..|. ::.|....|..:..:.:..||..:.::|:.|..|||:|   ...:.::|.|:::..|.:
  Rat   144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP---APNDDKECGVTEEPFYAL 205

  Fly   389 FATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGR 453
            |::..:||:||.|||.:|.::|..|     :|..:.::|.|.....:.        ..|.||:  
  Rat   206 FSSLGSFYIPLAVILVMYCRVYIVA-----KRTTKNLEAGVMKEMSNS--------KELTLRI-- 255

  Fly   454 FSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQ 518
                                            ::.|..|||                        
  Rat   256 --------------------------------HSKNFHEDT------------------------ 264

  Fly   519 IATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTT 583
                                                                             
  Rat   265 ----------------------------------------------------------------- 264

  Fly   584 ATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISA 648
             .|:..|.|.|                                                      
  Rat   265 -LSSTKAKGHN------------------------------------------------------ 274

  Fly   649 LSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQ 713
                                                             ||              
  Rat   275 -------------------------------------------------PR-------------- 276

  Fly   714 AHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA 778
                       ||||..:.|.:         ||:||||||.|:.|.|::||||||:......|.:
  Rat   277 -----------SSIAVKLFKFS---------REKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321

  Fly   779 ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL----FGGHRPVHYRSGKLXIVHA 839
            ..:..|:|..:..|||||||.|||:||...|.||::||.|||    .||.|              
  Rat   322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRR-------------- 372

  Fly   840 KRRRR 844
            :||||
  Rat   373 RRRRR 377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 69/186 (37%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 10/25 (40%)
TM helix 3 299..329 CDD:320454 20/29 (69%)
TM helix 4 340..362 CDD:320454 4/21 (19%)
TM helix 5 383..412 CDD:320454 11/28 (39%)
7tm_GPCRs <743..816 CDD:475119 35/72 (49%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 14/24 (58%)
Adra1bNP_058687.2 7tmA_alpha1B_AR 46..359 CDD:320449 126/592 (21%)
TM helix 1 47..73 CDD:320449 9/28 (32%)
TM helix 2 80..106 CDD:320449 10/25 (40%)
TM helix 3 118..148 CDD:320449 20/29 (69%)
TM helix 4 160..183 CDD:320449 4/22 (18%)
TM helix 5 200..229 CDD:320449 11/28 (39%)
TM helix 6 287..317 CDD:320449 17/38 (45%)
TM helix 7 327..352 CDD:320449 14/24 (58%)
Nuclear localization signal. /evidence=ECO:0000250 368..378 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 474..515
Blue background indicates that the domain is not in the aligned region.

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