Protein Alignment 5-HT1A and dop-3

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001024908.2
• Gene: dop-3 / 188499
• WormBaseID: WBGene00020506
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 671
• Identity: 167/671 - (24%)
• Similarity: 292/671 - (43%)
• Gaps: 144/671 - (21%)

  Fly   217 EDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP 281
            |.....:|......|.|.|:..:.:.|||.||.::..||:||.|.|.|:.||||:|..||..||.
 Worm    12 ESPLMVVLWRVAAGVFLPLVPTMAVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDFMVAIGVMS 76

  Fly   282 LGAVYEISQ-GWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYI-HSRTSNRVF 343
            .|..||.:. .|.||...|.::.:.||.|.|||||:|:||::|||.|:.: |.|. :.....|..
 Worm    77 FGVYYEWNDFKWGLGSFFCHVYQALDVACSTASILNLLAISLDRYIAIGHPISYAQYGARGGRAM 141

  Fly   344 MMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWK 408
            :.|..||..:|.|:|....| .:|  ::..:.|:|.::... :.:.::..:|::|.:.::.||..
 Worm   142 ISITIVWGVSVAVALPLLLG-VNP--MEENDLQECELANPY-FNMISSIFSFFIPCIAMIILYTI 202

  Fly   409 IYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASG 473
            |::..|:|...|..|....:.|:                            |..||  :.|.|..
 Worm   203 IFRRLRQRERARSLRQAQRSEND----------------------------KISSA--LLGGAQI 237

  Fly   474 GRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAK 538
            .|.:|....|.|:.:  :.:..|.:|:..:.|.:..:| ||....|.:.::.:.      |.|..
 Worm   238 ARQMGKHFKNRTDQI--LLEISFQTSSFPTMSESSEDA-STISPMINSFNNFLP------KKTPY 293

  Fly   539 SSAAVNGMAPSGRQEDDG--QRPEHGEQED------REELEDQDEQVGPQPTTATSAMTAAGTNE 595
            .|.::..:...|...:..  :|||..::::      |:.:|..|::.      :::.:|:..|:.
 Worm   294 PSTSIPAIPECGSMPNLTIIERPEAEKEKEISIMDLRDTVEMLDDKY------SSAILTSFQTSR 352

  Fly   596 SEDQCKANGVEVLEDPQLQQQLEQVQQL---QKSVKSGGGGGASTSNATTITSISALSPQ----- 652
            |                ..::||::...   ..|||.......:|.:.|:.|.:..:.|:
 Worm   353 S----------------FGEELEEILPFIDGSNSVKHSREQLHTTRSNTSTTRLLDVKPELRSIS 401

  Fly   653 TPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP----RSRQPTTPQQQPH-- 711
            .|:.|.       ...::.|::.|...:|:    || ::....|.|    :|:..|..:...:
 Worm   402 VPSIQD-------EKKLSQKSNDLPFSHQN----GT-HKQKLLPNPGILMKSKSTTLLKTNGYMD 454

  Fly   712 -----QQAHQQQ------------------QQQQQLSSIANPMQKVNK--------RKETLEAKR 745
                 :.:|::.                  .:.:...|::......||        :|.|.:.:|
 Worm   455 TDSLNRNSHKKSLADLLANDEFSFSDSMRVYKNRLFKSLSRATSGWNKPRPSRHMVKKATKQMRR 519

  Fly   746 ERKAAKTLAIITGAFVVCWLPFFVMALTMPLC------AACQISDSVASLFL--WLGYFNSTLNP 802
            |.||..|||::...|:.|||||||:.|:..:|      :||.   ....|:|  ||||.||:|||
 Worm   520 EHKATVTLAVVLAVFLFCWLPFFVLHLSNSICLIIDENSACV---GFLPLYLATWLGYLNSSLNP 581

  Fly   803 VIYTIFSPEFRQAFKRILFGG 823
            :|||:|...||.||:.||..|
 Worm   582 LIYTVFDQRFRNAFRNILSCG 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	64/188 (34%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	16/29 (55%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	5/28 (18%)
		7tm_GPCRs	<743..816	CDD:475119	36/80 (45%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	14/26 (54%)
dop-3	NP_001024908.2	7tmA_D2-like_dopamine_R	22..>204	CDD:320181	63/185 (34%)
		TM helix 1	23..49	CDD:320181	8/25 (32%)
		TM helix 2	56..82	CDD:320181	12/25 (48%)
		TM helix 3	95..125	CDD:320181	16/29 (55%)
		TM helix 4	138..161	CDD:320181	7/22 (32%)
		TM helix 5	177..204	CDD:320181	4/27 (15%)
		7tm_GPCRs	<515..595	CDD:475119	36/82 (44%)
		TM helix 6	524..546	CDD:410628	11/21 (52%)
		TM helix 7	563..588	CDD:410628	14/24 (58%)