DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and tyra-3

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_001024805.1 Gene:tyra-3 / 187427 WormBaseID:WBGene00006475 Length:592 Species:Caenorhabditis elegans


Alignment Length:759 Identity:194/759 - (25%)
Similarity:309/759 - (40%) Gaps:214/759 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 LAAAAASASVAAAAARITAKAA-----HRALTTKQDATSSPASSPALQLIDMDNNYTNVAVGLGA 171
            |:|.:...|:.|.:..|..:||     ..:::|.:.:.|.|:|:.|        ..|:..|    
 Worm    10 LSAKSDFESIMAWSVFIYIQAALGGSLWTSISTPEGSVSLPSSTTA--------TITSTTV---- 62

  Fly   172 MLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLM 236
                ..:.:...:|..|.:.|.:.|...:.      |.|.......|.|..|        .|.::
 Worm    63 ----TPVWVASKNSIPFADTLGSNSPLSEY------LPVKLCLGIHDVFIAL--------FLVML 109

  Fly   237 ILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI-SQGWILGPELCD 300
            ||:||.||:.|:.::::.:.::...|.|:.|||.|||.|..:|||:..:..: :..|.||..||.
 Worm   110 ILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLGRFLCR 174

  Fly   301 IWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGW 364
            :|.:.|||.||||||:|..|::|||:|:|: :.|..:|:......::..||..:.:|...|   |
 Worm   175 MWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPP---W 236

  Fly   365 KDPDYLQRI---------EQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRR 420
            ..|.:...|         |..||..|..|:|::::...:||:||||:|.:|:||::.|.:|    
 Worm   237 VIPSWNLFIDNNNNTGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASER---- 297

  Fly   421 RPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNST 485
                                 ..|.|..:...|.|...:||...                  |..
 Worm   298 ---------------------EALMRQSVGTCRLSNRLTKTQQK------------------NQR 323

  Fly   486 NTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSG 550
            |.:.|       :|...|::|             ..|:|          :..:.:.:|..:..:.
 Worm   324 NNLRT-------ASAPHSRTR-------------VQVNH----------NCGRVNYSVRPVEYAN 358

  Fly   551 RQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQ 615
            |.| :..:|.| |:.|..:.||       .|....|  ..|||.     |..:...|...|.   
 Worm   359 RVE-NSLKPSH-ERFDSTDCED-------SPPNGDS--LEAGTT-----CNISMSLVTNSPP--- 404

  Fly   616 QLEQVQQLQKSVKSGGGGGASTSNATTITSISAL--SPQTPTSQG--VGIAAAAAGPMTAKTSTL 676
                 ..|||..|:        |......|::.:  |..||..:.  ||:|     |..:|    
 Worm   405 -----NGLQKEAKN--------SMERECHSLADIVNSADTPVRKNTEVGVA-----PSLSK---- 447

  Fly   677 TSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPH---QQAHQQQQQQQQLSSIANPMQKVNKRK 738
                                  |:|| ...:.||:   |:||:..|       |..|.:.|...|
 Worm   448 ----------------------RARQ-CNARLQPNNLLQKAHEHYQ-------INGPGKAVRGSK 482

  Fly   739 ETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVA---------SLFLWLG 794
            |.:...|||||.||:.|:...|::||:|||:|.|....     |||.||         ..|||||
 Worm   483 EKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVF-----ISDPVAESPIYRITSEFFLWLG 542

  Fly   795 YFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKLXIVH 838
            |.||.|||:|||:::.:||:.|:.:|..|....|.|:..: .:|
 Worm   543 YSNSVLNPIIYTMYNGDFRRCFRDLLSFGCVQHHRRTMSVKKLH 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 67/196 (34%)
TM helix 1 228..254 CDD:320454 8/25 (32%)
TM helix 2 261..287 CDD:320454 12/25 (48%)
TM helix 3 299..329 CDD:320454 17/29 (59%)
TM helix 4 340..362 CDD:320454 4/21 (19%)
TM helix 5 383..412 CDD:320454 12/28 (43%)
7tm_GPCRs <743..816 CDD:475119 37/81 (46%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 17/33 (52%)
tyra-3NP_001024805.1 7tmA_tyramine_R-like 101..>300 CDD:320189 71/234 (30%)
TM helix 1 101..127 CDD:320189 10/33 (30%)
TM helix 2 134..160 CDD:320189 12/25 (48%)
TM helix 3 173..203 CDD:320189 17/29 (59%)
TM helix 4 215..238 CDD:320189 5/25 (20%)
TM helix 5 264..289 CDD:320189 10/24 (42%)
7tm_GPCRs <486..564 CDD:475119 37/82 (45%)
TM helix 6 494..516 CDD:320189 10/21 (48%)
TM helix 7 532..557 CDD:320189 14/24 (58%)

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