DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and ser-2

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001024339.1	Gene:	ser-2 / 182110	WormBaseID:	WBGene00004777	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	633	Identity:	155/633 - (24%)
Similarity:	248/633 - (39%)	Gaps:	231/633 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LINGTGGLNVTTSKVAEDDFTQLLRMAV---TSVLLG-----LMILVTIIGNVFVIAAIILERNL 257
            :||.:..::.||....:...|.:...::   ..::||     ::|.:|::||..|:.|:...|.|
Worm    24 VINASSAVSTTTLPPLDIPMTSMKPPSIIPTVELVLGTITYLVIIAMTVVGNTLVVVAVFSYRPL 88

  Fly   258 QNVANYLVASLAVADLFVACLVMPLGAVYEISQG-WILGPELCDIWTSCDVLCCTASILHLVAIA 321
            :.|.||.:.|||.:||.||..||||..|..::.| |:||..:|..:|:.|:|.||:|||:|.|||
Worm    89 KKVQNYFLVSLAASDLAVAIFVMPLHVVTFLAGGKWLLGVTVCQFFTTADILLCTSSILNLCAIA 153

  Fly   322 VDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVS 385
            :|||||:.| |:|...||:..|.::|..||..::::|:.|..||.  ::.:.:.:..|.:|.:.:
Worm   154 LDRYWAIHNPINYAQKRTTKFVCIVIVIVWILSMLISVPPIIGWN--NWQENMMEDSCGLSTEKA 216

  Fly   386 YQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLR 450
            :.||:...:|::||||::.:|.||:.:||:||...|.|.....:.|.:.|..       :| ::.
Worm   217 FVVFSAAGSFFLPLLVMVVVYVKIFISARQRIRTNRGRSALMRIQNAEGDDD-------YR-KMS 273

  Fly   451 LGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTS 515
            :.|.|...::|.|.||...|      |.:.||.:|.|.                    :.|.||.
Worm   274 IKRASVESARTSSRVGEKTP------LVIADGQTTVTT--------------------LAAHSTD 312

  Fly   516 GNQI---ATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQV 577
            |..:   .|..|:                         :..::|
Worm   313 GGSLPKDETTKHM-------------------------KYHNNG--------------------- 331

  Fly   578 GPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATT 642
                                 .||....:|.||
Worm   332 ---------------------SCKVKVKDVKED-------------------------------- 343

  Fly   643 ITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQ 707
                                                  :.:|
Worm   344 --------------------------------------EGNP----------------------- 347

  Fly   708 QQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMAL 772
                                 ||...:.|| |.:...:|::||||:|:|...|..|||||||..:
Worm   348 ---------------------NPTAVLRKR-EKISVAKEKRAAKTIAVIIFVFSFCWLPFFVAYV 390

  Fly   773 TMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ..|.|..|::...|...|.||||.||:|||.:|.|.:.|||:|||:||
Worm   391 IRPFCETCKLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKIL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	72/195 (37%)
		TM helix 1	228..254	CDD:320454	8/33 (24%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	10/28 (36%)
		7tm_GPCRs	<743..816	CDD:355774	34/72 (47%)
		TM helix 6	747..772	CDD:341315	14/24 (58%)
		TM helix 7	784..809	CDD:341315	13/24 (54%)
ser-2	NP_001024339.1	7tm_1	74..423	CDD:278431	136/566 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810