DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and DRD4

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000788.2 Gene:DRD4 / 1815 HGNCID:3025 Length:419 Species:Homo sapiens


Alignment Length:611 Identity:143/611 - (23%)
Similarity:201/611 - (32%) Gaps:251/611 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 SVLLG--LMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG- 291
            :.|:|  |:|...:.||..|..::..||.||...|..:.|||.|||.:|.||:||....|:..| 
Human    36 AALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGA 100

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAV-TNIDYIHSRTSNRVFMMIFCVWTAAVI 355
            |:|.|.|||...:.||:.|||||.:|.||:|||:.|| ..:.|.....|.|..::|...|..:..
Human   101 WLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAA 165

  Fly   356 VSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQ-------TA 413
            |:.....|..|   ::..:...|.: :|..|.|:::.|:|::|..::|.|||..::       ..
Human   166 VAAPVLCGLND---VRGRDPAVCRL-EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVAR 226

  Fly   414 RKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGV----SGPASGG 474
            |.::|.|.||         :|.|..                  ..|.|..|..:    .||....
Human   227 RAKLHGRAPR---------RPSGPG------------------PPSPTPPAPRLPQDPCGPDCAP 264

  Fly   475 RALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKS 539
            .|.||..|                                                         
Human   265 PAPGLPRG--------------------------------------------------------- 272

  Fly   540 SAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANG 604
                    |.|                              |..|.:|                 
Human   273 --------PCG------------------------------PDCAPAA----------------- 282

  Fly   605 VEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPM 669
                  |.|                                     ||.|           .|| 
Human   283 ------PSL-------------------------------------PQDP-----------CGP- 292

  Fly   670 TAKTSTLTSCNQSHP-----LCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIAN 729
                    .|....|     .||:....|......:..|.||.|                     
Human   293 --------DCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQ--------------------- 328

  Fly   730 PMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLG 794
                ..:|:......|||||.:.|.::.|||::||.||||:.:|..||.||.:...:.|...|||
Human   329 ----TRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLG 389

  Fly   795 YFNSTLNPVIYTIFSPEFRQAFKRIL 820
            |.||.|||||||:|:.|||..|::.|
Human   390 YVNSALNPVIYTVFNAEFRNVFRKAL 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 65/193 (34%)
TM helix 1 228..254 CDD:320454 7/25 (28%)
TM helix 2 261..287 CDD:320454 12/25 (48%)
TM helix 3 299..329 CDD:320454 17/30 (57%)
TM helix 4 340..362 CDD:320454 4/21 (19%)
TM helix 5 383..412 CDD:320454 10/35 (29%)
7tm_GPCRs <743..816 CDD:475119 38/72 (53%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 14/24 (58%)
DRD4NP_000788.2 7tmA_D4_dopamine_R 38..411 CDD:320434 141/603 (23%)
TM helix 1 38..62 CDD:320434 7/23 (30%)
TM helix 2 69..95 CDD:320434 12/25 (48%)
TM helix 3 108..138 CDD:320434 16/29 (55%)
TM helix 4 150..173 CDD:320434 4/22 (18%)
TM helix 5 189..218 CDD:320434 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..264 11/60 (18%)
4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P 249..312 23/237 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..336 5/43 (12%)
TM helix 6 339..369 CDD:320434 15/29 (52%)
TM helix 7 379..404 CDD:320434 14/24 (58%)

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