DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and DRD3

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000787.2 Gene:DRD3 / 1814 HGNCID:3024 Length:400 Species:Homo sapiens


Alignment Length:244 Identity:54/244 - (22%)
Similarity:86/244 - (35%) Gaps:61/244 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   847 SQTTVQFLNRLRF-----PEDYV-LRSGPRESIITGQKYFKDSLTMDALDI----DGFVNGINPF 901
            :::|:.||:|..|     |..:: |.|....:.:.    .|||...||...    .|.|.|:.|.
Human   158 TESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVD----MKDSYDADASTFCFPDSGDVGGLPPL 218

  Fly   902 DFITLHDDQYIPGNVTFDSLEIEESLDVRGAVHGKHMDKFLDNPSLLQTKLLEAACEFNEVVVNG 966
            .|..    |..|.:.|....|:..|.          .:...|....|:|||     ...|:....
Human   219 PFCM----QTSPHSKTVSESELSTSA----------TELLQDYMLTLRTKL-----SSQEIQQFA 264

  Fly   967 PIYVDQLDGYDLDHFLRSV--VYVD---------EPYVEINASKHYRSLHFYEPIRIE------S 1014
            .:..:..:|..:..|..|:  :|.|         .|::....|:|:.  :|.|.|.::      :
Human   265 ALLHEYRNGASIHEFCISLRQLYGDSRKFLLLGLRPFIPEKDSQHFE--NFLETIGVKDGRGIIT 327

  Fly  1015 NMIGEIHLDELLTKSTDQTINVSMVLGNVFFNRVQVHGLFGGINVTEWD 1063
            :..|. |...|.|.|| .|||.:...|:.........|       .|||
Human   328 DSFGR-HRRALSTTST-STINGNRTTGSPDDRSAPSEG-------DEWD 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454
TM helix 1 228..254 CDD:320454
TM helix 2 261..287 CDD:320454
TM helix 3 299..329 CDD:320454
TM helix 4 340..362 CDD:320454
TM helix 5 383..412 CDD:320454
7tm_GPCRs <743..816 CDD:475119
TM helix 6 750..772 CDD:410628
TM helix 7 784..809 CDD:410628
DRD3NP_000787.2 7tmA_D3_dopamine_R 30..394 CDD:320436 54/244 (22%)
TM helix 1 31..57 CDD:320436
TM helix 2 64..87 CDD:320436
TM helix 3 103..133 CDD:320436
TM helix 4 150..168 CDD:320436 3/9 (33%)
TM helix 5 185..210 CDD:320436 5/28 (18%)
TM helix 6 322..352 CDD:320436 9/31 (29%)
TM helix 7 362..387 CDD:320436 4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

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