Protein Alignment 5-HT1A and DRD2

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 159/598 - (26%)
• Similarity: 240/598 - (40%)
• Gaps: 201/598 - (33%)

  Fly   230 SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWIL 294
            :.||.|:|.|.:.|||.|..|:..|:.||...|||:.|||||||.||.||||.....|:...|..
Human    38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102

  Fly   295 GPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSN--RVFMMIFCVWTAAVIVS 357
            ....|||:.:.||:.||||||:|.||::|||.||......::|.|:  ||.:||..||..:..:|
Human   103 SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTIS 167

  Fly   358 LAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRP 422
            ....||      |...:|.:|::: :.::.|:::..:||||.:|.|.:|.|||...|    |||.
Human   168 CPLLFG------LNNADQNECIIA-NPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR----RRRK 221

  Fly   423 RPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNT 487
            |     ||..:       .::..|..||                  .|         :.||.|:.
Human   222 R-----VNTKR-------SSRAFRAHLR------------------AP---------LKGNCTHP 247

  Fly   488 VNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQ 552
                ||.:..:  |..||                                      ||..|..|:
Human   248 ----EDMKLCT--VIMKS--------------------------------------NGSFPVNRR 268

  Fly   553 EDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQL 617
            ..:..|
Human   269 RVEAAR----------------------------------------------------------- 274

  Fly   618 EQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQS 682
             :.|:|:..:                  :|:.||...|..         .|:......||..:.|
Human   275 -RAQELEMEM------------------LSSTSPPERTRY---------SPIPPSHHQLTLPDPS 311

  Fly   683 HPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIAN-----PMQKVNKRKETLE 742
            |      :...|||:    .|..|::..|.:.|.:..:..::.::.|     .::.:::||  |.
Human   312 H------HGLHSTPD----SPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRK--LS 364

  Fly   743 AKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTI 807
            .::|:||.:.|||:.|.|::||||||:..:....| .|.|...:.|.|.||||.||.:||:|||.
Human   365 QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC-DCNIPPVLYSAFTWLGYVNSAVNPIIYTT 428

  Fly   808 FSPEFRQAFKRIL 820
            |:.|||:||.:||
Human   429 FNIEFRKAFLKIL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	75/184 (41%)
		TM helix 1	228..254	CDD:320454	10/23 (43%)
		TM helix 2	261..287	CDD:320454	16/25 (64%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	7/23 (30%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	34/72 (47%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	155/592 (26%)
		TM helix 1	36..62	CDD:320435	10/23 (43%)
		TM helix 2	69..92	CDD:320435	16/22 (73%)
		TM helix 3	107..137	CDD:320435	18/29 (62%)
		TM helix 4	152..170	CDD:320435	6/17 (35%)
		TM helix 5	186..211	CDD:320435	8/24 (33%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		52/347 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		15/87 (17%)
		TM helix 6	366..396	CDD:320435	14/29 (48%)
		TM helix 7	405..430	CDD:320435	13/24 (54%)