Protein Alignment 5-HT1A and dop-1

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001370620.1
• Gene: dop-1 / 180714
• WormBaseID: WBGene00001052
• Length: 460
• Species: Caenorhabditis elegans
• Alignment Length: 601
• Identity: 137/601 - (22%)
• Similarity: 220/601 - (36%)
• Gaps: 218/601 - (36%)

  Fly   232 LLGL---MILVTIIGNVFVIAAIILERNL-QNVANYLVASLAVADLFVACLVMPLGAVYEISQGW 292
            ||||   :|::.:.||:.|.|||:.:|:| :...|..:.||||:||.|:.|||...||.:|...|
 Worm     8 LLGLFSVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYW 72

  Fly   293 ILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIV 356
            ..|...|..|.|.|:..||||||:|.||::||||.::. :.||......|:..:|..||..:..:
 Worm    73 PFGQFYCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIVLVWLISAGI 137

  Fly   357 SLAP-QFGWKDPDYLQRIE-QQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHR 419
            ..|| .||:.....:..:. ...|.:...:.|.:.::..:|::|.:|::.||.|:|..|||.:.
 Worm   138 GAAPLGFGFGSKVTINNLTGLPVCEMRLPLPYAIGSSMVSFFLPAMVMVILYTKLYLYARKHVR- 201

  Fly   420 RRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNS 484
                               :..|:|.
 Worm   202 -------------------SIKTQLQ--------------------------------------- 208

  Fly   485 TNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPS 549
                   :.|.|....:.|:....|.|.:..|.         ||......:|.:::..|:
 Worm   209 -------QATSFLIMQLASEKIREVTAATLKGE---------ALLPPDSPATERTTMTVS----- 252

  Fly   550 GRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQ 614
                      .|..:.              ..||.|:|....|..::..|.|...:
 Worm   253 ----------RHYSRR--------------STTTTTTATPRRGDKKTSSQNKVESI--------- 284

  Fly   615 QQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSC 679
                                                                     :||..:..
 Worm   285 ---------------------------------------------------------RTSIFSKL 292

  Fly   680 NQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK 744
            |.   ||.|..::..:|:    .|.||      .||.:       |:|:
 Worm   293 NF---LCPTRFKNQRSPQ----DPHTP------AAHNR-------SNIS---------------- 321

  Fly   745 RERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFS 809
             ::||..||.:|.|.|:|||||||.:.:..........|.::.:: .||||.||:.||:||:||:
 Worm   322 -DQKARLTLGVIMGTFLVCWLPFFTVNILRAWLPEIFSSKTIMAV-TWLGYANSSANPLIYSIFN 384

  Fly   810 PEFRQAFKRIL---FG 822
            .:||:|||:|:   ||
 Worm   385 RDFRRAFKKIIVRVFG 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	65/187 (35%)
		TM helix 1	228..254	CDD:320454	11/24 (46%)
		TM helix 2	261..287	CDD:320454	13/25 (52%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	6/22 (27%)
		TM helix 5	383..412	CDD:320454	8/28 (29%)
		7tm_GPCRs	<743..816	CDD:475119	29/72 (40%)
		TM helix 6	750..772	CDD:410628	12/21 (57%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
dop-1	NP_001370620.1	7tmA_Ap5-HTB1-like	7..391	CDD:320193	131/590 (22%)
		TM helix 1	7..33	CDD:320193	11/24 (46%)
		TM helix 2	41..67	CDD:320193	13/25 (52%)
		TM helix 3	79..109	CDD:320193	17/29 (59%)
		TM helix 4	121..143	CDD:320193	6/21 (29%)
		TM helix 5	166..195	CDD:320193	8/28 (29%)
		TM helix 6	320..350	CDD:320193	15/46 (33%)
		TM helix 7	359..384	CDD:320193	12/25 (48%)