Protein Alignment 5-HT1A and dop-6

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001359889.1
• Gene: dop-6 / 180706
• WormBaseID: WBGene00016037
• Length: 692
• Species: Caenorhabditis elegans
• Alignment Length: 699
• Identity: 155/699 - (22%)
• Similarity: 260/699 - (37%)
• Gaps: 236/699 - (33%)

  Fly   222 QLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVY 286
            :||:.....::|.::.||.|:||:.|:||:...::||...|:|:.|||:|||.|...|||.....
 Worm    18 ELLQPEWAYLVLSIVPLVCILGNLMVVAAVWTTKSLQTPTNHLLVSLAMADLIVGAFVMPFSIYL 82

  Fly   287 EISQ-GWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCV 349
            .::: .|.|...:|..:...||...|:||:|||.|::||..|.|. .:|...:...||::.|...
 Worm    83 SVNRLHWHLPLFVCYFYCVLDVAASTSSIIHLVLISIDRLVAATKPAEYKTVKHRKRVYLAIAIT 147

  Fly   350 WTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTAR 414
            |..::.:||....|:........:.:..|.:...: |.:.::...||:|.|:::..|..|:.|.|
 Worm   148 WIFSIALSLPLGTGFNTRTSYFLVIEHHCGIYNPI-YMLGSSIFAFYLPCLIMIFTYGYIFYTLR 211

  Fly   415 KRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGL 479
            ||                           |..::|:                   ..:||:.||.
 Worm   212 KR---------------------------LRAIQLQ-------------------EMAGGQFLGF 230

  Fly   480 VDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVN 544
            .                                       |.||::...|.|          :|.
 Worm   231 G---------------------------------------ADVSNITTSAIQ----------SVI 246

  Fly   545 GMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLE 609
            |:||..|.....::|...:.|:                  |:|..|:..|:||
 Worm   247 GIAPKNRNMITWEKPLLKKIEE------------------TAAEHASSLNDSE------------ 281

  Fly   610 DPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTS---QGVGIAAA--AAGPM 669
                   .||:|.:.::|.....|  |..| |||..    .|..|.|   :.|.:...  .:||:
 Worm   282 -------REQLQTILEAVHPSSSG--SQEN-TTIEE----DPDRPPSVLLEAVTLKCEIDTSGPI 332

  Fly   670 TAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQ--------QQQQQLSS 726
            ........:.|.|.......|...|....:|....|.:::.|  :||.|        ::.::|.|
 Worm   333 LELPRPTYTKNMSRRFSDAVNSISSRGRMKSVSFGTSRKRRH--SHQPQGNREVVTSEESKKLHS 395

  Fly   727 IANP------MQKVN-----------------------------------------------KRK 738
            :..|      |::::                                               |.|
 Worm   396 LKPPLVEKRKMRRLSEMISDWERPSRSSISNMYLYARRESVYIARKKLAGLKDWALDLLAKLKSK 460

  Fly   739 ETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSV--ASLFLW------LGY 795
            :.:..:||.:|.|.:|.:...|:|||||||    |:.:....::..:|  |.|.:|      |||
 Worm   461 QGMAIRRETRATKLVATVMVVFLVCWLPFF----TLNMIKIYKLIFNVWSADLEIWFHWFTALGY 521

  Fly   796 FNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKLXIVHAKRRRR 844
            .||:||..||:..:|:||.:|:|:|  |.|            .:.||:|
 Worm   522 LNSSLNFFIYSTINPKFRHSFRRLL--GFR------------RSSRRQR 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	55/187 (29%)
		TM helix 1	228..254	CDD:320454	9/25 (36%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	13/29 (45%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	7/28 (25%)
		7tm_GPCRs	<743..816	CDD:475119	30/80 (38%)
		TM helix 6	750..772	CDD:410628	10/21 (48%)
		TM helix 7	784..809	CDD:410628	13/32 (41%)
dop-6	NP_001359889.1	7tmA_amine_R-like	24..>217	CDD:320098	60/220 (27%)
		TM helix 1	24..50	CDD:320098	9/25 (36%)
		TM helix 2	57..84	CDD:320098	12/26 (46%)
		TM helix 3	96..126	CDD:320098	13/29 (45%)
		TM helix 4	138..158	CDD:320098	6/19 (32%)
		TM helix 5	180..210	CDD:320098	7/30 (23%)
		7tm_GPCRs	<464..542	CDD:475119	30/81 (37%)
		TM helix 6	472..494	CDD:410628	11/25 (44%)
		TM helix 7	513..535	CDD:410628	9/21 (43%)