Protein Alignment 5-HT1A and dop-2

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001256126.1
• Gene: dop-2 / 179347
• WormBaseID: WBGene00001053
• Length: 849
• Species: Caenorhabditis elegans
• Alignment Length: 831
• Identity: 197/831 - (23%)
• Similarity: 307/831 - (36%)
• Gaps: 257/831 - (30%)

  Fly   233 LGLMI--LVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGA-VYEISQGWIL 294
            |.|::  |:|::||:.||.:::..|.||:..|:|:..||||||.||.:|||... ||..:..|.|
 Worm    42 LSLIVIPLITLLGNLLVIISVLRYRALQSAINFLILGLAVADLLVAIIVMPYAVYVYVTNGDWYL 106

  Fly   295 GPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYI-HSRTSNRVFMMIFCVWTAAVIVS 357
            |..:|||:.:.||.|.|||||.|..|:.|||.||: .|.|. .|:...||:.:|..:|..::.::
 Worm   107 GNLMCDIYMASDVCCSTASILLLAVISFDRYRAVSLPIQYSRQSQNVKRVWTLIAVIWLVSLTLA 171

  Fly   358 LAPQFG--WKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKR---I 417
            ....||  .:.||    ....:|.. .:..:.:.::..:|.:|..::|.:|.:|....:||   .
 Worm   172 SPMVFGVNVRPPD----ANPYECRF-YNAEFSILSSMISFVIPCFLVLFVYIRIIIALKKREKAA 231

  Fly   418 HRRRPRPVDAAVNNNQPDGG----------------------AATDTKLHRLRLRLGRFSTAKSK 460
            ..||.:...|.....:||.|                      ||..:...|:| :..|...|...
 Worm   232 KMRREKNTIAHGLTMRPDTGEEQVDEEAAGRIVAGPVVNVMMAALPSMTRRMR-QFERHRRAIEL 295

  Fly   461 TG------SAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSR-----AGVEAPST 514
            .|      ..:.|.....||...| .|.:..:..|.....|.|:....|..|     |.|...::
 Worm   296 AGDEEWEEDELDVMDECCGGDDAG-DDDDDYHADNGQGVVEASAPRTTSMLRRIINAASVGTANS 359

  Fly   515 SGNQIATVSHLVALAKQQGKST--AKSSAAVNGMAPSGRQEDDGQRP--------EHGEQE-DRE 568
            :...:|:.|.:.|...|...:|  :.||.|......|...:..|..|        |.|... .|.
 Worm   360 TAQSVASASGMPAFFAQNISTTSPSSSSCARTTTTTSAIPKASGDLPLPMLLNEREFGNSSTPRS 424

  Fly   569 ELEDQDEQVG-----------------------PQPTTATSAMTAAGTNESEDQCKANGVEVLED 610
            .||...|.|.                       .||   ||:.|::|...|..         ::.
 Worm   425 SLESLSENVNVITNDFVSENCTTFSRRSSYADDSQP---TSSQTSSGDGRSYS---------IKG 477

  Fly   611 PQLQQQLEQ---VQQLQKSVKSGGGGGASTSNATTIT-------------SISALSPQTPTSQGV 659
            .:..:.|.:   .:..:|.||...|...:.|...:||             :||..||:.......
 Worm   478 QKRFRNLSRNYSTKHHRKVVKVNRGNSRNNSRTASITNQSDDALIPAIIRTISRKSPRLFRRDKT 542

  Fly   660 GI---AAAAAGPMT-------------------AKTSTL-----------------TSCNQSHPL 685
            .|   :...|.|:|                   .:|.|:                 |:.| |..|
 Worm   543 DIKKHSMILANPITEPPKEYRRVSMPIHPTNSQTETETISASRDIENLPTTTISRSTTAN-SAEL 606

  Fly   686 CGTANESPSTP-------------EPRS---RQPT------------------------------ 704
            .|:.::....|             |.|.   .|||
 Worm   607 LGSPDDFEKFPALITETVLEDVLAETREGCFMQPTVSFALTVREMEGNALNNLKGCSVESSRRVS 671

  Fly   705 -----------TPQQQPHQQAHQQQQQQQQLSSI---------ANPMQKVN-------------- 735
                       |....||...       |::.||         |:.::.|:
 Worm   672 QVDPPLAIQILTRPSLPHLDL-------QRMDSIGTTCSSKTRADSLRSVDSKGSKKSNRNGIAV 729

  Fly   736 -------------KRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA-----ACQI 782
                         |||.:...::|::|.|||.::.|.|:|||:||||:.:...:|.     :||:
 Worm   730 KLVKRAIKHEHSLKRKVSKAQRKEKRATKTLGVVVGVFLVCWVPFFVINILNAVCILLNKDSCQV 794

  Fly   783 SDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGK 833
            ...:.....|:||.||.:||:|||||:.|||:|||.|:||.:...|:.|.|
 Worm   795 GYDLFFYCTWIGYMNSFMNPIIYTIFNTEFRRAFKSIIFGRNSTRHHFSNK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	64/186 (34%)
		TM helix 1	228..254	CDD:320454	8/22 (36%)
		TM helix 2	261..287	CDD:320454	14/26 (54%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	4/21 (19%)
		TM helix 5	383..412	CDD:320454	5/28 (18%)
		7tm_GPCRs	<743..816	CDD:475119	32/77 (42%)
		TM helix 6	750..772	CDD:410628	12/21 (57%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
dop-2	NP_001256126.1	7tmA_D2-like_dopamine_R	38..>233	CDD:320181	66/195 (34%)
		TM helix 1	39..65	CDD:320181	8/22 (36%)
		TM helix 2	72..98	CDD:320181	13/25 (52%)
		TM helix 3	111..141	CDD:320181	17/29 (59%)
		TM helix 4	154..177	CDD:320181	4/22 (18%)
		TM helix 5	194..223	CDD:320181	5/28 (18%)
		7tm_GPCRs	<745..828	CDD:475119	33/82 (40%)
		TM helix 6	757..779	CDD:410628	12/21 (57%)
		TM helix 7	796..821	CDD:410628	11/24 (46%)