DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and ser-4

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_497452.1	Gene:	ser-4 / 175322	WormBaseID:	WBGene00004779	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	690	Identity:	191/690 - (27%)
Similarity:	271/690 - (39%)	Gaps:	266/690 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 TKQDATSSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLIN 203
            |..:.|:||:|.||..|         .||..|..|
Worm     5 TLLNLTASPSSQPATLL---------SAVARGTHL------------------------------ 30

  Fly   204 GTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTI----IGNVFVIAAIILERNLQNVAN-Y 263
                  |.......:.|:.:.|..|.:|:|..::||.|    |||:|||.|||:||:|:.... |
Worm    31 ------VDQFPAHAEIFSDIERPLVQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYY 89

  Fly   264 LVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAV 328
            |:.|||||||.|..:|.||||.:.::..|.||..:||.|.|.|||.||||||||||||:||||::
Worm    90 LIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSI 154

  Fly   329 TNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRI-EQQKCMVSQDVSYQVFATC 392
            |:|.|:.:||..|:.:|:..:|..::::||||..||||..:..|: :...|::||.:|||||:|.
Worm   155 TDICYVQNRTPKRITLMLAVIWFTSLLISLAPFAGWKDEGFSDRVLKSHVCLISQQISYQVFSTA 219

  Fly   393 CTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTA 457
            ..||:||:.|:.:||||.:.|:||..|.|.|   ..|....||.
Worm   220 TAFYIPLIAIICVYWKIMRAAKKRFKRERDR---RTVIRPPPDA--------------------- 260

  Fly   458 KSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATV 522
                                                       :|.|
Worm   261 -------------------------------------------IDEK------------------ 264

  Fly   523 SHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSA 587
                                 ..|.|
Worm   265 ---------------------KAMMP--------------------------------------- 269

  Fly   588 MTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQ 652
                   :...:|......|:.|                :::.||.|..|:           |.:
Worm   270 -------KKSKKCPLPPAVVISD----------------IQANGGTGGKTN-----------SIK 300

  Fly   653 TPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQ 717
            .|...                                |||.|:.....|..|.....|.....|:
Worm   301 NPPRH--------------------------------NESSSSASEEERTMTQTNHAPGDVTTQE 333

  Fly   718 QQQQQQLSSIANP--MQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAAC 780
            .:..:: :..:.|  :::..:.||:.|.||||||.:|||||||.||.||.|||::::..|:| .|
Worm   334 TKIDEE-NGRSKPGIVKRRRRTKESNEMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPIC-GC 396

  Fly   781 QISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            |||..:..:.|||||.||.|||:|||:||.:||.|||||:
Worm   397 QISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRII 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	94/191 (49%)
		TM helix 1	228..254	CDD:320454	15/29 (52%)
		TM helix 2	261..287	CDD:320454	15/26 (58%)
		TM helix 3	299..329	CDD:320454	23/29 (79%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	15/28 (54%)
		7tm_GPCRs	<743..816	CDD:355774	43/72 (60%)
		TM helix 6	747..772	CDD:341315	17/24 (71%)
		TM helix 7	784..809	CDD:341315	13/24 (54%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	170/592 (29%)
		TM helix 1	53..79	CDD:320454	13/25 (52%)
		TM helix 2	87..113	CDD:320454	15/25 (60%)
		TM helix 3	125..155	CDD:320454	23/29 (79%)
		TM helix 4	166..188	CDD:320454	7/21 (33%)
		TM helix 5	210..239	CDD:320454	15/28 (54%)
		TM helix 6	361..391	CDD:320454	20/29 (69%)
		TM helix 7	400..425	CDD:320454	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I910
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20148
Inparanoid	1	1.050	309	1.000	Inparanoid score	I1562
Isobase	1	0.950	-	0	Normalized mean entropy	S4767
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.820