Protein Alignment 5-HT1A and Htr5b

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_034613.2
• Gene: Htr5b / 15564
• MGIID: 96284
• Length: 370
• Species: Mus musculus
• Alignment Length: 641
• Identity: 152/641 - (23%)
• Similarity: 211/641 - (32%)
• Gaps: 302/641 - (47%)

  Fly   183 NDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFV 247
            :||...|..:.:..|.| ::.|           .|..|:....:.||  ||.|:|:.|.:.|:.|
Mouse    23 SDSPSSGRSMGSTPGGL-ILPG-----------REPPFSAFTVLVVT--LLVLLIVATFLWNLLV 73

  Fly   248 IAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG--WILGPELCDIWTSCDVLCC 310
            :..|:..|....|.:.||||.||:|:.||.|||||..|.|:|.|  |.||..||.:|.|.|||||
Mouse    74 LVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSVGRRWQLGRSLCHVWISFDVLCC 138

  Fly   311 TASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRI 373
            ||||.::.|||:||||.:| ::.|.....|....:||...|..:.:::||| .|||.:. |..|:
Mouse   139 TASIWNVAAIALDRYWTITRHLQYTLRTRSRASALMIAITWALSALIALAPLLFGWGEA-YDARL 202

  Fly   374 EQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGA 438
              |:|.|||:.||.||:||..||:||.|:|.:|||||:.|:.|..|||
Mouse   203 --QRCQVSQEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRFGRRR----------------- 248

  Fly   439 ATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDS 503
                                                                             
Mouse   249 ----------------------------------------------------------------- 248

  Fly   504 KSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDRE 568
              ||.|..|:|:                |.|
Mouse   249 --RAVVPLPATT----------------QAK---------------------------------- 261

  Fly   569 ELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGG 633
            |...:.|.|......||.....:|.:..|
Mouse   262 EAPPESEMVFTARRRATVTFQTSGDSWRE------------------------------------ 290

  Fly   634 GASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP 698
                                                                             
Mouse   291 ----------------------------------------------------------------- 290

  Fly   699 RSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVC 763
                                                         ::|::||..:.|:.|.||:|
Mouse   291 ---------------------------------------------QKEKRAAMMVGILIGVFVLC 310

  Fly   764 WLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRI 819
            |:|||:..|..||| ||.:.....|:||||||.||..||:|||.|:..:..|||.:
Mouse   311 WIPFFLTELISPLC-ACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSL 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	89/189 (47%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	19/29 (66%)
		TM helix 4	340..362	CDD:320454	6/22 (27%)
		TM helix 5	383..412	CDD:320454	17/28 (61%)
		7tm_GPCRs	<743..816	CDD:475119	33/72 (46%)
		TM helix 6	750..772	CDD:410628	10/21 (48%)
		TM helix 7	784..809	CDD:410628	14/24 (58%)
Htr5b	NP_034613.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		3/12 (25%)
		7tm_GPCRs	65..362	CDD:475119	135/580 (23%)
		TM helix 2	88..110	CDD:410628	14/21 (67%)
		TM helix 3	128..150	CDD:410628	13/21 (62%)
		TM helix 4	173..189	CDD:410628	4/15 (27%)
		TM helix 5	211..234	CDD:410628	12/22 (55%)
		TM helix 6	297..319	CDD:410628	10/21 (48%)
		TM helix 7	330..355	CDD:410628	14/24 (58%)