DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT1A and Htr5a

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:XP_006535694.1 Gene:Htr5a / 15563 MGIID:96283 Length:380 Species:Mus musculus


Alignment Length:602 Identity:143/602 - (23%)
Similarity:204/602 - (33%) Gaps:290/602 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 FTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGA 284
            |....|:.|.: |||.:...|...|:.|:|.|:..|....|.:.||||:|::|:.||.|||||..
Mouse    58 FLSAFRVLVLT-LLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSL 121

  Fly   285 VYEIS-QGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVF-MMI 346
            |:|:| :.|.||..||.:|.:||||||||||.::.|||:||||::| :::|. .||..||. :||
Mouse   122 VHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYT-LRTRKRVSNVMI 185

  Fly   347 FCVWTAAVIVSLAP-QFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIY 410
            ...|..:.::|||| .|||.: .|.:..|:  |.||::.||.||:|...||:||.|:|.:|||||
Mouse   186 LLTWALSTVISLAPLLFGWGE-TYSEPSEE--CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIY 247

  Fly   411 QTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGR 475
            :.|:.|:..|:                                                      
Mouse   248 RAAKFRMGSRK------------------------------------------------------ 258

  Fly   476 ALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSS 540
                     ||:|:.|                                                 
Mouse   259 ---------TNSVSPV------------------------------------------------- 265

  Fly   541 AAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGV 605
                              ||                                           .|
Mouse   266 ------------------PE-------------------------------------------AV 269

  Fly   606 EVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMT 670
            ||                              .|||                             
Mouse   270 EV------------------------------KNAT----------------------------- 275

  Fly   671 AKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVN 735
                       .||                                     |.:.::.:......
Mouse   276 -----------QHP-------------------------------------QMVFTVRHATVTFQ 292

  Fly   736 KRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTL 800
            ...:|...::|::||..:.|:.|.||:||.||||..|..||| :..:.....|:||||||.||..
Mouse   293 TEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFF 356

  Fly   801 NPVIYTIFSPEFRQAFK 817
            ||:|||.|:..:..|||
Mouse   357 NPLIYTAFNRSYSSAFK 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 87/189 (46%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 14/25 (56%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 9/23 (39%)
TM helix 5 383..412 CDD:320454 16/28 (57%)
7tm_GPCRs <743..816 CDD:355774 32/72 (44%)
TM helix 6 747..772 CDD:341315 12/24 (50%)
TM helix 7 784..809 CDD:341315 14/24 (58%)
Htr5aXP_006535694.1 7tmA_5-HT5 64..372 CDD:320451 138/593 (23%)
TM helix 1 66..90 CDD:320451 9/24 (38%)
TM helix 2 99..121 CDD:320451 13/21 (62%)
TM helix 3 138..160 CDD:320451 13/21 (62%)
TM helix 4 183..199 CDD:320451 5/15 (33%)
TM helix 5 221..244 CDD:320451 11/22 (50%)
TM helix 6 304..329 CDD:320451 12/24 (50%)
TM helix 7 340..365 CDD:320451 14/24 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

Return to query results.
Submit another query.