DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Htr5a

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_032340.2 Gene:Htr5a / 15563 MGIID:96283 Length:357 Species:Mus musculus


Alignment Length:602 Identity:143/602 - (23%)
Similarity:204/602 - (33%) Gaps:290/602 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 FTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGA 284
            |....|:.|.: |||.:...|...|:.|:|.|:..|....|.:.||||:|::|:.||.|||||..
Mouse    35 FLSAFRVLVLT-LLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSL 98

  Fly   285 VYEIS-QGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVF-MMI 346
            |:|:| :.|.||..||.:|.:||||||||||.::.|||:||||::| :::|. .||..||. :||
Mouse    99 VHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYT-LRTRKRVSNVMI 162

  Fly   347 FCVWTAAVIVSLAP-QFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIY 410
            ...|..:.::|||| .|||.: .|.:..|:  |.||::.||.||:|...||:||.|:|.:|||||
Mouse   163 LLTWALSTVISLAPLLFGWGE-TYSEPSEE--CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIY 224

  Fly   411 QTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGR 475
            :.|:.|:..|:                                                      
Mouse   225 RAAKFRMGSRK------------------------------------------------------ 235

  Fly   476 ALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSS 540
                     ||:|:.|                                                 
Mouse   236 ---------TNSVSPV------------------------------------------------- 242

  Fly   541 AAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGV 605
                              ||                                           .|
Mouse   243 ------------------PE-------------------------------------------AV 246

  Fly   606 EVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMT 670
            ||                              .|||                             
Mouse   247 EV------------------------------KNAT----------------------------- 252

  Fly   671 AKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVN 735
                       .||                                     |.:.::.:......
Mouse   253 -----------QHP-------------------------------------QMVFTVRHATVTFQ 269

  Fly   736 KRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTL 800
            ...:|...::|::||..:.|:.|.||:||.||||..|..||| :..:.....|:||||||.||..
Mouse   270 TEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLC-SWDVPAIWKSIFLWLGYSNSFF 333

  Fly   801 NPVIYTIFSPEFRQAFK 817
            ||:|||.|:..:..|||
Mouse   334 NPLIYTAFNRSYSSAFK 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 87/189 (46%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 14/25 (56%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 9/23 (39%)
TM helix 5 383..412 CDD:320454 16/28 (57%)
7tm_GPCRs <743..816 CDD:475119 32/72 (44%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 14/24 (58%)
Htr5aNP_032340.2 7tm_GPCRs 41..349 CDD:475119 138/593 (23%)
TM helix 1 43..67 CDD:410628 9/24 (38%)
TM helix 2 76..98 CDD:410628 13/21 (62%)
TM helix 3 115..137 CDD:410628 13/21 (62%)
TM helix 4 160..176 CDD:410628 5/15 (33%)
TM helix 5 198..221 CDD:410628 11/22 (50%)
TM helix 6 284..306 CDD:410628 11/21 (52%)
TM helix 7 317..342 CDD:410628 14/24 (58%)

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