| Sequence 1: | NP_001356890.1 | Gene: | 5-HT1A / 37196 | FlyBaseID: | FBgn0004168 | Length: | 846 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_032336.1 | Gene: | Htr1f / 15557 | MGIID: | 99842 | Length: | 366 | Species: | Mus musculus |
| Alignment Length: | 644 | Identity: | 163/644 - (25%) |
|---|---|---|---|
| Similarity: | 238/644 - (36%) | Gaps: | 288/644 - (44%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 180 LEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGN 244
Fly 245 VFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLC 309
Fly 310 CTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRI 373
Fly 374 EQQKCMVSQD-VSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRR-PRPVDAAVNNNQPDG 436
Fly 437 GAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNV 501
Fly 502 DSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQED 566
Fly 567 REELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGG 631
Fly 632 GGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTP 696
Fly 697 EPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFV 761
Fly 762 VCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT1A | NP_001356890.1 | 7tmA_5-HT1A_invertebrates | 227..>413 | CDD:320454 | 84/187 (45%) |
| TM helix 1 | 228..254 | CDD:320454 | 13/25 (52%) | ||
| TM helix 2 | 261..287 | CDD:320454 | 16/25 (64%) | ||
| TM helix 3 | 299..329 | CDD:320454 | 21/29 (72%) | ||
| TM helix 4 | 340..362 | CDD:320454 | 7/21 (33%) | ||
| TM helix 5 | 383..412 | CDD:320454 | 13/29 (45%) | ||
| 7tm_GPCRs | <743..816 | CDD:355774 | 39/72 (54%) | ||
| TM helix 6 | 747..772 | CDD:341315 | 18/24 (75%) | ||
| TM helix 7 | 784..809 | CDD:341315 | 12/24 (50%) | ||
| Htr1f | NP_032336.1 | 7tm_4 | 33..>155 | CDD:304433 | 63/122 (52%) |
| 7tm_1 | 41..347 | CDD:278431 | 140/563 (25%) | ||
| Agonist binding. /evidence=ECO:0000250 | 99..108 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 120..122 | 1/1 (100%) | |||
| Agonist binding. /evidence=ECO:0000250 | 306..310 | 3/3 (100%) | |||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 343..347 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167849919 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D310620at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X366 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.850 | |||||