DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and Htr1d

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001272411.1	Gene:	Htr1d / 15552	MGIID:	96276	Length:	374	Species:	Mus musculus

Alignment Length:	653	Identity:	164/653 - (25%)
Similarity:	241/653 - (36%)	Gaps:	292/653 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 DSSLFG--EMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVF 246
            :.||.|  :..:|||           ||||.:  .:.:..|.||:::. |:|.::.|.|::.|.|
Mouse     5 NQSLEGLPQEASNRS-----------LNVTGA--WDPEVLQALRISLV-VVLSVITLATVLSNAF 55

  Fly   247 VIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCT 311
            |:..|:|.:.|...||||:.|||..||.|:.||||:...|..::.|..|..|||||.|.|:.|||
Mouse    56 VLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120

  Fly   312 ASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQ 375
            ||||||..||:|||||:|: ::|...||:.....||..||..::.:|:.|.| |:.....:  |.
Mouse   121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHE--EM 182

  Fly   376 QKCMV-SQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAA 439
            ..|:| :..:||.:::||..||:|.::::.||.:||..||.||             .|.|.
Mouse   183 SDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRI-------------LNPPS---- 230

  Fly   440 TDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSK 504
                     |...||:||:..||||                 |:|..::|
Mouse   231 ---------LYGKRFTTAQLITGSA-----------------GSSLCSLN--------------- 254

  Fly   505 SRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREE 569
                   ||...:...||...:..
Mouse   255 -------PSLHESHTHTVGSPLFF----------------------------------------- 271

  Fly   570 LEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEV-LEDPQLQQQLEQVQQLQKSVKSGGGG 633
                                             |.|:: |.|..|:
Mouse   272 ---------------------------------NQVKIKLADSILE------------------- 284

  Fly   634 GASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP 698

Mouse   285 ----------------------------------------------------------------- 284

  Fly   699 RSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVC 763
                                                   ::.:.|.|||||.|||.||.|||::|
Mouse   285 ---------------------------------------RKRISAARERKATKTLGIILGAFIIC 310

  Fly   764 WLPFFVMALTMPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPV 827
            ||||||::|.:|:|. :|.|..::...|.||||.||.:||||||:|:.:|||||:::       |
Mouse   311 WLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKV-------V 368

  Fly   828 HYR 830
            |:|
Mouse   369 HFR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	76/187 (41%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	22/29 (76%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:355774	43/73 (59%)
		TM helix 6	747..772	CDD:341315	18/24 (75%)
		TM helix 7	784..809	CDD:341315	13/24 (54%)
Htr1d	NP_001272411.1	7tm_GPCRs	32..364	CDD:391938	149/597 (25%)
		TM helix 1	38..62	CDD:341315	8/24 (33%)
		TM helix 2	71..93	CDD:341315	13/21 (62%)
		TM helix 3	109..131	CDD:341315	15/21 (71%)
		Agonist binding. /evidence=ECO:0000250	111..120		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:341315	5/15 (33%)
		TM helix 5	192..215	CDD:341315	8/22 (36%)
		TM helix 6	294..319	CDD:341315	18/24 (75%)
		Agonist binding. /evidence=ECO:0000250	311..315		3/3 (100%)
		TM helix 7	332..357	CDD:341315	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	349..353		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840